Prognostic Value of BRAF and KRAS Mutations in MSI and MSS ...

Prognostic Value of BRAF and KRAS Mutations in MSI ... - PubMed

001) and KRAS-mutant patients (HR = 1.62, 95% CI = 1.38 to 1.91, P < .001) vs wild-type. No prognostic role of KRAS or BRAF mutations was seen ...

Regarding BRAF-mutant tumors, it has been suggested that BRAF V600E mutation is not influencing disease recurrence but only survival after ...

553O Prognostic value of KRAS and BRAF mutations in ...

In the largest analysis of the association of KRAS exon 2 and BRAFV600E mutations and disease outcome in resected stage III CC, either mutation was associated ...

Different prognostic values of KRAS exon 2 submutations and BRAF ...

Among the 7492 MSS tumors, 53.8% were DWT, 38.6% KRAS mutant, and 7.7% BRAFV600E mutant (Figure 1). Those patients with a BRAFV600E mutation in ...

Different prognostic values of KRAS exon 2 submutations and BRAF ...

... KRAS exon 2 submutations and BRAF V600E mutation in microsatellite ... Shi, et al. Prognostic value of BRAF and KRAS mutations in MSI and MSS stage III colon ...

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS ...

001) and KRAS-mutant patients (HR = 1.62, 95% CI = 1.38 to 1.91, P <. 001) vs wild-type. No prognostic role of KRAS or BRAF mutations was seen ...

The prognostic significance of KRAS and BRAF mutation status in ...

In addition, our data revealed 3 KRAS and BRAF co-mutated cases. Among these 3 cases, 2 had Gly13Asp KRAS mutations, 1 had a Gly12Asp mutation, ...

Prognostic Effect of BRAF and KRAS Mutations in Patients With ...

In contrast, KRAS mutations have no prognostic value in patients with MSI tumors, whereas the BRAF V600E mutation could be associated with ...

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS ...

Four thousand four hundred eleven tumors were evaluable for BRAF and KRAS mutations and mismatch repair status; 3934 were MSS and 477 were MSI. In MSS patients, ...

Prognostic value of KRAS and BRAF mutations in curatively ...

Patient characteristics according to KRAS or BRAF status are summarized in Table 1. MSI status was determined in all cases, whereas mutation status was not ...

CMS-dependent prognostic impact of KRAS and BRAFV600E ...

However, a comparison of the KRAS mutant gene expression signature between mutated and wild-type MSS tumors revealed the effect of KRAS mutations to be largest ...

Evaluating the Combination of Microsatellite Instability and Mutation ...

24. Sinicrope, F.A. ∙ Smyrk, T.C. ∙ Tougeron, D. ... Mutation-specific antibody detects mutant BRAFV600E protein expression in human ...

Context-dependent interpretation of the prognostic value of BRAF ...

Overall survival: prognostic value of BRAF and KRAS mutations within MSS and by tumor site. ... BRAF mutation in MSI-H tumors. As a ...

The Association Between Mutations in BRAF and Colorectal Cancer ...

In patients whose tumors were MSI-H, mutation of BRAF did not significantly affect survival time. Patients whose tumors had MSS with mutant BRAF ...

Prognostic value of microsatellite instability (MSI)/deficient mismatch ...

In the meta-analysis by Taieb et al., BRAFV600E mutations were associated with significantly poorer SAR in patients with either MSI/dMMR or MSS/pMMR tumours, ...

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS ...

This BRAF mutation, although rare, is detected in 5 to 10% of metastatic CRCs [15]; [16] . ... ... We found that the frequency of KRAS mutations in our series ...

Combination of microsatellite instability and BRAF mutation status ...

The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF V600E mutation in colorectal cancer (CRC)

Prognostic value of the combination of microsatellite instability and

Conclusion: Among the four subtypes according to MSI and BRAF mutation, MSS/BRAFmut was a poor prognostic factor, while MSS/BRAFwt and MSI/ ...

Microsatellite Instability and BRAF Mutation Testing in Colorectal ...

No evidence existed for a differential prognostic role of BRAF mutation by MSI status (Pinteraction > . ... Value of mismatch repair, KRAS, and BRAF mutations ...

The prognostic role of microsatellite instability, codon‐specific KRAS ...

In addition, the BRAFV600E mutation was a poor prognostic factor in tumors with MSI-L/MSS (P = 0.020). KRAS mutations were not prognostic ...