Prognostic impact of deficient DNA mismatch repair and KRAS and ...

Prognostic Impact of Deficient DNA Mismatch Repair and Mutations ...

Prognostic Impact of Deficient DNA Mismatch Repair and Mutations in KRAS, and BRAFV600E in Patients with Lymph Node-Positive Colon Cancer · Abstract · Grants and ...

Prognostic impact of deficient DNA mismatch repair in patients with ...

The prognostic impact of MMR depended on tumor site, and this interaction was validated in an independent cohort.

Prognostic Impact of Deficient DNA Mismatch Repair and KRAS and ...

In the subgroup of patients with microsatellite-stable CRC, a KRAS mutation was associated with a slightly worse prognostic value for recurrence ...

Prognostic Impact of Deficient DNA Mismatch Repair in Patients ...

The prognostic impact of MMR depended on tumor site, and this interaction was validated in an independent cohort. Among dMMR cancers, proximal tumors had ...

Prognostic Impact of Deficient DNA Mismatch Repair in Patients ...

The association of deficient DNA mismatch repair (dMMR) with prognosis in patients with colon cancer treated with adjuvant fluorouracil, leucovorin, and ...

Prognostic impact of deficient DNA mismatch repair and KRAS and ...

Prognostic impact of deficient DNA mismatch repair and KRAS and BRAF V600E mutations in patients with lymph-node-positive colon cancer · Overview · Fingerprint ...

Prognostic impact of high-risk factors and KRAS mutation in patients ...

In stage II colorectal cancer, deficient mismatch repair (dMMR) is associated with a good prognosis (3-6), and these patients can be followed up ...

Prognostic impact of deficient DNA mismatch repair in patients with ...

Patients and Methods: Resected, stage III colon carcinomas from patients (N = 2,686) randomly assigned to FOLFOX ± cetuximab (North Central Cancer Treatment ...

Impact of Deficient DNA Mismatch Repair on Disease-Free Survival ...

In the full study cohort, deficient DNA mismatch repair was detected in 314 (12%) of 2,580 tumors, and mutations in BRAF V600E and KRAS were ...

Prognostic Effect of BRAF and KRAS Mutations in Patients With ...

Microsatellite instability is a consequence of deficient DNA mismatch repair (MMR) that results in the accumulation of insertion and/or deletion ...

Prognostic Impact of Deficient DNA Mismatch Repair in ... - Sci-Hub

Frank A. Sinicrope, Michelle R. Mahoney, Thomas C. Smyrk, Stephen. N. Thibodeau, Garth D. Nelson, Daniel. J. Sargent, and Steven R. Alberts,.

O-0029 Prognostic Impact of DNA Mismatch Repair Status and ...

Colon cancers with deficient function of the DNA mismatch repair (dMMR) system develop microsatellite instability (MSI) and have been associated with a ...

Prognostic Impact of Deficient DNA Mismatch Repair and Mutations ...

The current status of BRAFV600E and KRAS mutations and MMR status as prognostic biomarkers in stage III colon cancers are reviewed.

Prognostic impact of mutation profiling in patients with stage II and III ...

KRAS, BRAF and NRAS mutations do not have major prognostic value in stage II and III colon cancer, subtypes of gene mutations should be further investigated.

(PDF) Prognostic Impact of Deficient DNA Mismatch Repair in ...

dMMR was detected in 314 (12%) of 2,580 tumors, of which 49.3% and 10.6% had BRAF(V600E) or KRAS mutations, respectively. MMR status was not ...

Implications of mismatch repair-deficient status on management of ...

Lynch syndrome (LS) accounts for approximately 3-4% of all CRCs and one third of all dMMR/MSI-associated CRC. It is inherited autosomal dominant and is caused ...

CMS-dependent prognostic impact of KRAS and BRAFV600E ...

In contrast, the poor prognosis of KRAS mutations was limited to MSS tumors with CMS2/CMS3 epithelial-like gene expression profiles (OS: KRAS mutation versus ...

Prognostic Impact of Deficient DNA Mismatch Repair and KRAS and ...

Bazan V, Migliavacca M, Zanna I, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K- ...

Prognostic and Predictive Values of Mismatch Repair Deficiency in ...

Knowledge of mismatch repair (MMR) status has important implications for disease diagnosis, surgical intervention, and adjuvant treatment ...

The Clinical Impact of the Genomic Landscape of Mismatch Repair ...

MMR-deficient tumors have peculiar properties, including early-onset metastatic potential but generally favorable prognosis, and remarkable response to immune ...