Progress in the Development of Preventative Drugs for Cisplatin ...

No FDA-approved therapies for the prevention of cisplatin-induced hearing loss have been developed. Still, numerous protective compounds have been identified.

This review summarizes the clinical and preclinical studies of the most effective small-molecule candidates currently in clinical trials.

Progress in the Development of Preventative Drugs for Cisplatin ...

Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone in chemotherapeutic regimens. Unfortunately, its use in the ...

Progress in the Development of Preventative Drugs for Cisplatin ...

Since its approval by the FDA in 1978, cisplatin has become a cornerstone in chemotherapeutic regimens and has been included on the World Health ...

Polymeric nanoparticles loaded with dexamethasone or α ...

The aim of this work is the development of highly protective agents to be administered locally within the middle ear to avoid cisplatin-induced ototoxicity, ...

Progress in the Development of Preventative Drugs for Cisplatin ...

This review summarizes the clinical and preclinical studies of the most effective small-molecule candidates currently in clinical trials, ...

Progress in the Development of Preventative Drugs for Cisplatin ...

Over the past few decades, enormous effort has been put forth to find protective agents that selectively protect against the ototoxic side effects of cisplatin ...

Progress in the Development of Preventative Drugs for Cisplatin ...

Request PDF | Progress in the Development of Preventative Drugs for Cisplatin-Induced Hearing Loss | Cisplatin is a highly effective treatment for malignant ...

Progress in the Development of Preventative Drugs for Cisplatin ...

Oral D-methionine (MRX-1024) Significantly Protects Against Cisplatin-Induced Hearing Loss: A Phase II Study in Humans. Proceedings of the 32nd Annual Midwinter ...

Prevention of cisplatin-induced hearing loss in children - Frontiers

PM is approved for cisplatin treated children aged 1 month to 18 years with localized solid tumors by the Food and Drug Administration (FDA), ...

Association of Sodium Thiosulfate With Risk of Ototoxic Effects From ...

6. Hazlitt RA, Min J, Zuo J. Progress in the development of preventative drugs for cisplatin-induced hearing loss. J Med Chem. 2018;61 ...

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ...

New insights into cisplatin ototoxicity - Brock - 2022 - Cancer

It is heartening to see that progress is being made in the development of drug-induced ototoxicity prevention, although much more still needs to ...

Use of Sodium Thiosulfate as an Otoprotectant in Patients With ...

Delayed systemic administration of STS, at 6 hours after the cisplatin infusion, does not affect cisplatin-induced inhibition of tumor growth or ...

Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

Platinum-based chemotherapeutic drugs, such as cisplatin, carboplatin, and oxaliplatin, are widely used in the treatment of solid malignant tumors in both adult ...

Dabrafenib protects from cisplatin-induced hearing loss ... - JCI Insight

... cisplatin treatment. Currently, there is only 1 ... Progress in the development of preventative drugs for cisplatin-induced hearing loss.

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and ...

Discovery – Cisplatin and The Treatment of Testicular and Other ...

Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support. Ongoing research has aimed at ...

Platinum-based drugs for cancer therapy and anti-tumor strategies

Therefore, the third generation of platinum clinical drug oxaliplatin was developed. The mechanism of action of oxaliplatin is similar to cisplatin, without ...

Cisplatin ototoxicity mechanism and antagonistic intervention strategy

Therefore, prevention of cisplatin ototoxicity is currently more important than treatment. First of all, the indications for the use of ...