Proposed mechanism of LPA signaling in osteoclasts. LPA is ...

Download scientific diagram | Proposed mechanism of LPA signaling in osteoclasts. LPA is released by neighboring osteoblasts and binds to LPA receptors on ...

exploring Lysophosphatidic Acid (LPA) signaling in malignant bone ...

LPA binds to LPARs to activate downstream signaling pathways, playing functional roles in tumor progression. One such pathway is the PI3K/Akt ...

Lysophosphatidic Acid Signals through Multiple Receptors in ... - NCBI

Focal application of LPA elicited transient increases in cytosolic calcium concentration ([Ca2+]i), with 50% of osteoclasts responding at ∼400 n ...

Lysophosphatidic Acid Receptor Type 1 (LPA1) Plays a Functional ...

Cell Biology. Lysophosphatidic Acid Receptor Type 1 (LPA1) Plays a Functional Role in Osteoclast Differentiation and Bone Resorption Activity*.

LPAR2 REGULATES LPA-INDUCED OSTEOCLAST SEALING ...

I propose that there is an external signaling mechanism involved in this ring expansion, induced by LPA. The siRNA knock-down data strongly suggests that ...

LPA Increases Tumor Growth and Bone Destruction Through ...

Conditioned medium from LPA-stimulated PC-3 cells containing enhanced levels of osteoclastogenic cytokines facilitated osteoclast formation. Histopathologically ...

The emerging role of lysophosphatidic acid (LPA) in skeletal biology

Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most mammalian cell types. Although LPA has an established ...

LPA receptor signaling: pharmacology, physiology, and ...

Also, LPA2 activation can inhibit EGF-induced migration and invasion of pancreatic cancer cells through the G12/13/Rho pathway (144). These data lend support to ...

Effects of pertussis toxin and Rho-associated kinase blocker on...

Intriguing data from another study also showed that LPA/LPAR1 signalling in the bone potentiates osteoclast activity through Ca 2+ /nuclear factor of activated ...

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA ...

While providing an overview of LPAR signaling, these examples also reveal gaps in our knowledge regarding the mechanisms of LPA action at the receptor level.

LPA Increases Tumor Growth and Bone Destruction Through ...

However, little is known on which signaling molecules are induced from tumor cells by LPA stimulation, support osteoclast formation and promote bone resorption ...

Lysophosphatidic acid receptor 4 regulates osteogenic and ...

Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/β-catenin signaling pathway and ...

ATX-LPA 1 axis contributes to proliferation of chondrocytes ... - Nature

... LPA receptor signaling is essential for normal development and implicated in various (patho)physiological processes, but underlying mechanisms ...

LPA receptor signaling: pharmacology, physiology, and ...

Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and ...

Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to ... - MDPI

... also discuss new working hypotheses emerging from the interplay of ATX/LPA with well-established signaling pathways regulating bone mass.

LPA receptor signaling: pharmacology, physiology, and ...

There are two major synthetic pathways for LPA. In the first pathway, the precursor phospholipids (phosphatidylcholine, phosphatidylserine, or ...

The Role of Lysophosphatidic Acid in Adult Stem Cells

LPC is an intermediate in multiple lipid metabolic pathways. These results suggest the distinct signaling mechanisms of LPA receptors are ...

Autotaxin Implication in Cancer Metastasis and - ProQuest

This new mechanism offers a new vision of how ATX/LPA ... LPA production and signaling [66]. Our group ... LPA controls the bone resorption activity of osteoclasts ...

Platelet-derived lysophosphatidic acid supports the progression of ...

... suggested to be a fourth LPA receptor (LPA4) (4). Additionally, the ... signaling by LPA is a general mechanism of metastatic tumor growth.

Expression of the type 1 lysophosphatidic acid receptor in ...

Taken together these results suggest a new role for LPA in bone mass control via bone mineralization and osteocyte function. Keywords: Lpar1, ...