- Protein Degradation and PROTACs🔍
- PROTAC targeted protein degraders🔍
- Assays and technologies for developing proteolysis targeting ...🔍
- Protein Degradation Resource Center🔍
- Targeted Protein Degradation for Drug Discovery🔍
- Protein Degradation Assays🔍
- Targeted protein degradation🔍
- PROTAC® Degradation Assays🔍
Protein Degradation Assays
Protein Degradation and PROTACs - Promega Corporation
Live-cell protein degradation assays are useful for researchers studying the basic science of the UPS and for assay developers monitoring the effect of small ...
PROTAC targeted protein degraders: the past is prologue - Nature
... degraded by PROTAC molecules. They based their analysis on several aspects of protein degradation mentioned here, such as availability of a ...
Assays and technologies for developing proteolysis targeting ...
Targeted protein degradation by small-molecule degraders represents an emerging mode of action in drug discovery.
Protein Degradation Resource Center | Thermo Fisher Scientific - US
Protein degradation has recently emerged as a selective and potentially effective approach to identify new drug targets, ...
Targeted Protein Degradation for Drug Discovery
Key Questions To Consider When Developing Protein Degraders. Promega offers a portfolio of cell-based assays for use in development of effective protein ...
Protein Degradation Assays - PROTAC Screening - Reaction Biology
A set of assays to investigate the binding of a drug to target, the structure of the drug-target complex, and the degradation of the target from the cell.
Targeted protein degradation - Revvity
To support your research, Revvity's no-wash assay kits offer an efficient alternative to western blotting, streamlining workflows and ...
PROTAC® Degradation Assays - LifeSensors
... assays (fluorescent proteins, HiBiT) and LifeSensors' high throughput ubiquitination and degradation assays. Our targeted protein degradation team has a ...
Assays for Targeted Protein Degradation - Bio-Techne
Multiple orthogonal assays, exploring target engagement by the Degrader and ternary complex formation, target protein ubiquitination and degradation.
Quantitative Cell-based Protein Degradation Assays to Identify and ...
Our work establishes a high-throughput screening-compatible pipeline for identification and classification of small molecules, cDNAs, or siRNAs that target ...
Targeted protein degradation & next-generation ... - BMG Labtech
You can read more about assay options for targeted protein degradation in the BMG LABTECH blog Cell-based protein degrader assays for ...
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation
We develop a novel assay platform for identification and characterization of macromolecules capable of inducing targeted degradation of oncogenic phosphatase ...
High-Throughput Quantitative Assay Technologies for Accelerating ...
The field of targeted protein degradation is an emerging area for drug discovery in which small molecules are used to recruit E3 ubiquitin ligases to catalyze ...
Targeted Protein Degradation Services - Charles River Laboratories
Unlike traditional drug discovery programs that focus upon protein inhibition approaches, protein degradation assays specifically target your protein of ...
Induced protein degradation for therapeutics: past, present, and future
Structural analysis of these degrons and subsequent computational docking studies revealed that a wide range of zinc fingers with varying amino ...
Solutions for Targeted Protein Degradation Drug Discovery
Characterize and validate the warhead end of novel bifunctional degraders using KINOMEscan™, BROMOscan™, BCL2scan, STAT SH2 ligand binding assays or custom-made ...
Cell-based protein degrader assays for microplates - BMG Labtech
The choice of assay for targeted protein degradation studies is crucial. But what is the preferred assay and detection technology for your ...
Monitoring and deciphering protein degradation pathways inside cells
For PROTAC compounds, this has been particularly challenging using either biochemical or cellular assay approaches. Biochemical assays are highly informative ...
Protein Degradation using the Ubiquitin-Proteasome Pathway
... proteins for degradation, a process known as targeted protein degradation. ... Click-iT Plus assays detect protein translation events while enabling the ...
Targeted Protein Degradation Archives - WuXi Biology
... Assays, DNA-Encoded Library (DEL), Targeted Protein Degradation ... Resource Topic: Cell-based Assays, Oncology, Structural Biology, Targeted Protein Degradation, ...