- Protein degraders enter the clinic — a new approach to cancer therapy🔍
- PROTAC targeted protein degraders🔍
- Protein degradation resources🔍
- Protein degraders enter the clinic🔍
- Protein degraders🔍
- Induced protein degradation for therapeutics🔍
- Targeted Protein Degradation🔍
- Natural Product|Inspired Targeted Protein Degraders🔍
Protein Degraders
Protein degraders enter the clinic — a new approach to cancer therapy
Protein degraders are showing promising activity as cancer therapies. Herein, we review advances in protein degrader development.
PROTAC targeted protein degraders: the past is prologue - Nature
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have ...
Protein degradation is the process by which proteins are naturally destroyed in a cell in order to maintain protein homeostasis, or an equilibrium of proteins ...
Protein degraders enter the clinic - a new approach to cancer therapy
Heterobifunctional protein degraders, such as PROteolysis TArgeting Chimera (PROTAC) protein degraders, constitute a novel therapeutic ...
Protein degraders - from thalidomide to new PROTACs
In this article, I introduce the history of protein degraders, from the development of thalidomide to the latest PROTACs and related technologies.
Induced protein degradation for therapeutics: past, present, and future
Biologically, degraders remove all activity of a protein, including scaffolding function, while enzyme inhibitors remove activity of the protein ...
Targeted Protein Degradation - Bio-Techne
Protein Degraders are bifunctional compounds comprising 3 components: an E3 ubiquitin ligase ligand, a linker, and a ligand for a target protein of interest.
Natural Product-Inspired Targeted Protein Degraders
The use of NP-inspired targeted protein degraders has been confirmed to be a promising strategy to treat many human conditions, including cancer ...
Central Nervous System Targeted Protein Degraders - PMC
Autophagy-targeting chimeras (AUTACs) are bifunctional molecules that degrade their targets by accessing the previously mentioned autophagy ...
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ...
New drug reveals a key mechanism to overcome resistance to ...
Protein degraders, a novel approach in drug discovery, show promise to tackle diseases previously thought to be untreatable. Unlike traditional ...
Targeted protein degrader development for cancer - Cell Press
Targeted protein degradation (TPD) is an emerging therapeutic modality that has expanded the druggable proteome for cancer treatment.
Transforming the Discovery of Targeted Protein Degraders: The ...
The mechanistic modeling framework presented here lays the foundation for rigorous model-informed discovery and development of TPDs.
Targeted Protein Degraders- The Druggability Perspective
In AbTACs, one arm of the molecule is an antibody fragment that specifically recognizes and binds to the target protein of interest. The arm ...
NJ Bio, Inc. — Targeted Protein Degraders
Targeted protein degradation (TPD) is a revolutionary therapeutic strategy that is refining the precepts of classical drug discovery. TPDs ...
New insights on protein degraders open doors to treatment for ...
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' which ...
Analyzing the Toxicity of Targeted Protein Degraders - ToXchange
This blog reports on the Workshop Session titled “Targeted Protein Degradation Therapeutics: Opportunities and Challenges” that was held during the 2023 SOT ...
Targeted protein degraders are redefining how small molecules look ...
Targeted protein degradation, a way of sending bad-behaving proteins to the cellular trash compactor, is a hot new area in drug discovery.
Protein Degrader Building Blocks - Sigma-Aldrich
Discover protein degrader building blocks for creating libraries, like PROTAC ® molecules, for efficient target protein degradation in cell screenings.
Clinical Translation of Targeted Protein Degraders - Kong - 2023
Targeted protein degradation (TPD) has emerged as a potentially transformational therapeutic modality with considerable promise.