Protein O|GlcNAcylation in multiple immune cells and its therapeutic ...

Protein O-GlcNAcylation in multiple immune cells and its therapeutic ...

O-GlcNAcylation is widespread in the immune system, which engages in multiple physiologic and pathophysiologic processes. There is substantial ...

Protein O-GlcNAcylation in multiple immune cells and its therapeutic ...

O-GlcNAcylation is a post-translational modification of proteins that involves the addition of O-GlcNAc to serine or threonine residues of ...

Protein O-GlcNAcylation in multiple immune cells and its therapeutic ...

Protein O-GlcNAcylation is closely related to the activation of immune signaling and inflammatory responses. An expanding body of research has ...

(PDF) Protein O-GlcNAcylation in multiple immune cells and its ...

PDF | O-GlcNAcylation is a post-translational modification of proteins that involves the addition of O-GlcNAc to serine or threonine ...

O-GlcNAcylation Modification in Immune Cells: Potential ...

O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells.

role of O-GlcNAcylation in innate immunity and inflammation

After glucose is taken up into cells through the transporter GLUT protein ... Although OGT-mediated O-GlcNAcylation has been observed in many ...

O-GlcNAcylation and immune cell signaling: A review of known and ...

This review attempts to mark out the known regulatory roles of O-GlcNAcylation in key signal transduction pathways and specific protein functions in the immune ...

O-GlcNAcylation promotes tumor immune evasion by inhibiting PD ...

Immunofluorescence assays detecting the colocalization of these two proteins in cells showed similar observations (Fig. 4D). The turnover rate ...

O-GlcNAcylation: roles and potential therapeutic target for bone ...

An accumulation of immune cells and expansion of resident stromal and vascular cells in the ... the role of protein O-GlcNAcylation in various ...

O-GlcNAcylation and immune cell signaling - ScienceDirect.com

... the altered stability, activity, and localization of various proteins. As discussed above, three things are needed to advance the field: the biochemical ...

O-GlcNAcylation and its role in the immune system

Like OGT, OGA is capable of binding to several different protein substrates to exert its functions. ... of O-GlcNAcylation in various lineages of ...

Editorial: O-GlcNAcylation and the immune system - Frontiers

... proteins in the immune cells and immune ... O-GlcNAcylation regulates function of individual immune cell types and its therapeutic potential.

Protein O-GlcNAcylation Regulates Innate Immune Cell Function.

This is of particular importance to innate immune cell functions due to the essential role of protein phosphorylation in regulating many aspects of innate ...

O-GlcNAcylation in immunity and inflammation: An intricate system ...

... of O-GlcNAcylation without affecting OGT protein ... Since O-GlcNAcylation's involvement in various immune pathways appears complicated, the ...

Hexokinase HK3-mediated O-GlcNAcylation of EP300 - Nature

... of macrophages once it enters these immune cells. These ... Protein O-GlcNAcylation in multiple immune cells and its therapeutic potential.

O-GlcNAcylation at the center of antitumor immunity - ScienceDirect

The success of checkpoint blockade or adoptive cell therapy ... The lineage stability and suppressive program of regulatory T cells require protein O- ...

A novel link between metabolism and immune function: O-GlcNAc ...

The cross-talk between these two modifications in turn regulates many cellular processes. However, little is known about how O-GlcNAc glycosylation ...

Targeting immunometabolism as an anti-inflammatory strategy

Through the differential metabolic requirements of effector and regulatory immune cell populations we have a therapeutic opportunity that allows ...

The role of O‐GlcNAcylation in immunity against infections

... the function and fate of various immune cells has been extensively studied. ... Since the discovery of O-GlcNAcylation, many proteins that ...

Oncolytic Virus Enables the Immune System to Attack Tumors

One of the most important findings in cancer research in the past two decades is that tumors can create force field-like protection against ...