Proteins Recognizing DNA

Proteins Recognizing DNA: Structural Uniqueness and Versatility of ...

Proteins use a wide range of DNA-binding structural motifs, such as homeodomain (HD), helix-turn-helix (HTH), and high-mobility group box (HMG) to recognize DNA ...

The role of DNA shape in protein–DNA recognition - Nature

The recognition of specific DNA sequences by proteins is thought to depend on two types of mechanism: one that involves the formation of ...

Methods for Detecting Protein-DNA Interactions - US

The ChIP assay method allows analysis of DNA–protein interactions in living cells by treating the cells with formaldehyde or other crosslinking reagents in ...

Proteins Recognizing DNA: Structural Uniqueness and Versatility of ...

Proteins in the form of transcription factors (TFs) bind to specific DNA sites that regulate cell growth, differentiation, and cell ...

DNA recognition and bending - ScienceDirect.com

DNA-binding proteins recognize their DNA targets not only through the formation of specific contacts with the nucleotide bases but also through inherent ...

Recognition of Specific DNA Sequences: Molecular Cell

The ability of a protein to bind selectively to a particular DNA site in the genome is the foundation upon which transcriptional regulatory pathways are built.

Structural insights into the DNA recognition mechanism by the ...

Specificity in protein–DNA recognition arises from the synergy of several factors that stem from the structural and chemical signatures encoded ...

Review Recognition of Specific DNA Sequences - ScienceDirect.com

Proteins recognize a particular sequence by having a surface that is chemically complementary to that of the DNA, forming a series of favorable electrostatic ...

Protein-DNA recognition mechanisms and specificity - SpringerLink

The mechanism of specific DNA recognition by a protein must satisfy two requirements. First, the probability of incorrect binding should be very small.

Protein−DNA binding in the absence of specific base-pair recognition

We identify a new protein−DNA binding mechanism induced by DNA sequence symmetry in the absence of specific base-pair recognition.

DNA mismatches reveal conformational penalties in protein ... - Nature

Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established ...

Identifying DNA-binding proteins by combining support vector ...

A DNA-binding protein identification method (SVM-PSSM-DT) by combining PSSM Distance Transformation with support vector machine (SVM).

Origins of Specificity in Protein-DNA Recognition - Annual Reviews

Specific interactions between proteins and DNA are fundamental to many biological processes. In this review, we provide a revised view of ...

Protein–DNA binding: complexities and multi-protein codes

In the mid 1970s, motivated by early X-ray crystal structures of proteins and DNA, Seeman et al. (1) proposed a protein–DNA recognition code based on hydrogen ...

How can a protein recognize a specific sequence of DNA? - Quora

Proteins can interact with DNA either specifically or non-specifically. In the case of non-specific interactions, the sequence of ...

Linking DNA-binding proteins to their recognition sequences ... - PNAS

We have developed a high-throughput method for identifying sequences recognized by DNA-binding proteins that uses an array of transcription factors.

DNA-binding protein - Wikipedia

DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA.

Structural Uniqueness and Versatility of DNA-Binding Domains in ...

Proteins Recognizing DNA: Structural Uniqueness and Versatility of DNA-Binding Domains in Stem Cell Transcription Factors · Dhanusha Yesudhas, Maria Batool, +2 ...

DNA Interactions with Proteins - News-Medical

Mechanism for protein–DNA recognition ... The aromatic residues and positively charged residues are the predominant interacting partners together ...

How to find the DNA motif recognised by a protein? - Biostars

I want to find the DNA motif recognized by this factor, I have tried to find this information in different databases (uniprot, P2CS, and some other) but I can' ...