Puromycin|sensitive Aminopeptidase Protects Against Aggregation

Puromycin-sensitive aminopeptidase protects against aggregation ...

By promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity.

Puromycin-sensitive aminopeptidase protects against aggregation ...

A major function of proteasomes and macroautophagy is to eliminate misfolded potentially toxic proteins. Mammalian proteasomes, however ...

(PDF) Puromycin-sensitive aminopeptidase protects against ...

Mammalian proteasomes, however, cannot cleave polyglutamine (polyQ) sequences and seem to release polyQ-rich peptides. Puromycin-sensitive ...

Puromycin-sensitive aminopeptidase protects against aggregation ...

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. by Fiona M Menzies, Raphael Hourez, Sara Imarisio, ...

Puromycin‐sensitive aminopeptidase is the major peptidase ...

To identify these key peptidases, we investigated the degradation in cell extracts of model Q‐rich fluorescent substrates and peptides containing 10–30 Q's.

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes ...

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) is a novel modifier of TAU-induced neurodegeneration with neuroprotective effects via direct proteolysis of TAU ...

Figure 4 from Puromycin-sensitive aminopeptidase (PSA/NPEPPS ...

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy · Biology, Medicine. Human Molecular Genetics · 2010.

Puromycin-sensitive aminopeptidase protects against aggregation ...

Williams, Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications, Curr. Top Dev. Biol., № 76, с. 89

NPEPPS (aminopeptidase puromycin sensitive)

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. 33. 21320871, 2011, Puromycin-sensitive ...

606793 - AMINOPEPTIDASE, PUROMYCIN-SENSITIVE; NPEPPS

Aminopeptidases are a group of exopeptidases that hydrolyze amino acids from the N terminus of a peptide substrate. Puromycin-sensitive aminopeptidase (EC ...

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is ...

In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxicity in a Drosophila model system. We ...

Structure of puromycin-sensitive aminopeptidase and polyglutamine ...

11.14, UniProt P55786), a zinc metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as well as peptides released from the ...

Degradation of Tau Protein by Puromycin-Sensitive Aminopeptidase ...

Tau, a microtubule associated protein, aggregates into intracellular paired helical filaments (PHFs) by an unknown mechanism in Alzheimer's ...

Puromycin-sensitive aminopeptidase protects against aggregation ...

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy · Human Molecular Genetics 19(23): 4573-4586 · 2010 · Related ...

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin ...

... puromycin-sensitive aminopeptidase (PSA/Npepps). PSA protected against tau-induced neurodegeneration in vivo, whereas PSA loss of function ...

Puromycin‐sensitive aminopeptidase is the major peptidase ...

Puromycin‐sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.

Puromycin-sensitive aminopeptidase protects against aggregation ...

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Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of ...

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) was recently identified as a major peptidase acting on neurotoxic TAU protein and protecting ...

Recombinant Human Puromycin-sensitive aminopeptidase ...

... protect against accumulation of aggregation-prone proteins and proteotoxicity PMID: 20829225; attenuated proteolysis of FTDP-17 mutant tau may be explained ...

Increased Anxiety and Impaired Pain Response in Puromycin ...

Molecular analysis indicated that the mutated gene encodes a puromycin-sensitive aminopeptidase (Psa; EC 3.4.11.14), whose functionsin vivo ...