Pyruvate|Carboxylase|Mediated Anaplerosis Promotes Antioxidant ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant ...

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant ...

Pyruvate-Carboxylase-Mediated Anaplerosis. Promotes Antioxidant Capacity by Sustaining TCA. Cycle and Redox Metabolism in Liver. Graphical ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant ...

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver · Abstract.

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. by David A Cappel, ...

Pyruvate carboxylase and cancer progression

Given its critical role in TCA cycle anaplerosis, PC may therefore serve as a target to prevent cancer cell proliferation and cancer progression ...

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

1. Cappel, D.A. ∙ Deja, S. ∙ Duarte, J.A.G. ... Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA ...

Pyruvate carboxylase deficiency: Mechanisms, mimics and ...

Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that ...

Ins and Outs of the TCA Cycle: The Central Role of Anaplerosis

Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver. Cell Metab 29 ...

The Presence of Pyruvate Carboxylase in the Human Brain and its ...

Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver. Cell Metab ...

Pyruvate anaplerosis is a targetable vulnerability in persistent ...

We demonstrate that LSCs have increased pyruvate anaplerosis, mediated by increased mitochondrial pyruvate carrier 1/2 (MPC1/2) levels and ...

Pyruvate anaplerosis is a mechanism of resistance to ... - BMC Cancer

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer · Abstract ...

Requirement of hepatic pyruvate carboxylase during fasting, high fat ...

9. Cappel, D.A. ∙ Deja, S. ∙ Duarte, J.A.G. ... Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA ...

[PDF] Pyruvate carboxylase deficiency: mechanisms, mimics and ...

Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis ... Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA ...

Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological ...

Cappel DA, Deja S, Duarte JAG, et al. Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox ...

Gluconeogenesis Flux in Metabolic Disease - Annual Reviews

12. Cappel DA, Deja S, Duarte JAG, Kucejova B, Inigo M et al. 2019. Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by ...

Endogenous renal adiponectin drives gluconeogenesis through ...

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. Cell Metab ...

Substrate–Enzyme Competition Attenuates Upregulated Anaplerotic ...

Increased carboxylation of pyruvate via cytosolic malic enzyme (ME), producing malate, enables “anaplerotic” influx of carbon into the citric ...

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid ...

Reciprocal regulation of cardiac β-oxidation and pyruvate ...

55. Cappel, D.A. ∙ Deja, S. ∙ Duarte, J.A.G. ... Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox ...