RET Proto|Oncogene

5979 - Gene ResultRET ret proto-oncogene [ (human)] - NCBI

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins.

RET proto-oncogene ... The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of ...

The RET proto-oncogene in human cancers - Nature

The activation of the RET proto-oncogene contributes to the development of human cancers in two different ways.

RET proto-oncogene in the development of human cancer - PubMed

The RET proto-oncogene, located on chromosome subband 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest.

RET gene: MedlinePlus Genetics

RET gene. URL of this page: https://medlineplus.gov/genetics/gene/ret/. RET gene. ret proto-oncogene. Email this page to a friend Facebook X Pinterest Download ...

A comprehensive overview of the role of the RET proto-oncogene in ...

In this Review, we discuss the pathogenic, diagnostic and prognostic roles of the RET proto-oncogene in patients with PTC and MTC.

Proto-oncogene tyrosine-protein kinase receptor Ret ... - UniProt

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, ...

Roles of the RET Proto-oncogene in Cancer and Development

RET rearrangements have been detected in a variety of human cancers, including thyroid, lung, colorectal, breast, and salivary gland cancers. Moreover, point ...

Orphanet: RET-ret proto-oncogene - Genes

RET - ret proto-oncogene. Synonym(s): CDHF12, CDHR16, PTC, RET receptor tyrosine kinase, RET51, cadherin-related family member 16, rearranged during ...

RET Proto-Oncogene - an overview | ScienceDirect Topics

RET proto-oncogene (RET). RET is a kinase fusion mutation that affects the MAPK, PI3K, and STAT3 pathways. Wiesner and colleagues reported RET mutations in 2 of ...

RET Proto-Oncogene Testing - Medical Clinical Policy Bulletins

In summary, RET proto-oncogene tests can be used to identify familial disease-causing RET point mutations in members of families known to be affected by ...

RET Proto-Oncogene in the Development of Human Cancer

Abstract. The RET proto-oncogene, located on chromosome subband 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural ...

RET Proto-Oncogene—Not Such an Obvious Starting Point ... - MDPI

Mutations and fusions of RET (rearranged during transfection) gene are detected in a few common types of tumors including thyroid or non-small cells lung ...

RET Gene - GeneCards | RET Protein | RET Antibody

Complete information for RET gene (Protein Coding), Ret Proto-Oncogene, including: function, proteins, disorders, pathways, orthologs, ...

The RET Proto-Oncogene in Multiple Endocrine Neoplasia Type 2 ...

Unlike the susceptibility genes in most inherited cancer syndromes, RET is a proto-oncogene, which means that a single activating mutation on ...

RET Proto-Oncogene: A Review and Update of Genotype ...

Abstract. Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. Associations ...

Entry - *164761 - RET PROTOONCOGENE; RET - OMIM

Family lineage tracing and pedigree construction revealed not only that 4 descendants had medullary thyroid carcinoma but also that 4 living affected family ...

RET oncogene - ScienceDirect.com

Abstract. RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the ...

REThinking the role of the RET oncogene in breast cancer - Frontiers

This review aims to recapitulate the existing evidence about the role of RET oncogene in breast cancer, from its pathogenic and potentially prognostic role,

RET (multiple endocrine neoplasia type 2 gene) - UpToDate

RET gene — The rearranged during transfection (RET) proto-oncogene is a transmembrane glycoprotein receptor with tyrosine kinase activity ...

RET proto-oncogene

Factor

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules.RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.