RNA and neuronal function

RNA and neuronal function: the importance of post-transcriptional ...

The brain represents an organ with a particularly high diversity of genes that undergo post-transcriptional gene regulation through multiple ...

RNA regulation in brain function and disease 2022 (NeuroRNA)

Recent research integrates novel technologies and methods from the interface of RNA biology and neuroscience.

Editorial: RNA Localization and Localized Translation in Neurons

The active transport of RNAs bound by RNA binding proteins (RBPs) and their local translation have functional consequences for both, with roles in neurogenesis, ...

Mapping RNA signatures in neurons - Max-Planck-Gesellschaft

The importance of precise temporal regulation of ELAV expression and its consequences in the course of neuronal development is because ELAV is a ...

RNA granules in neuronal plasticity and disease - Cell Press

RNA granules are dynamic entities controlling the spatiotemporal distribution and translation of RNA molecules. In neurons, a variety of RNA ...

The long noncoding RNA Synage regulates synapse stability and ...

The nuclear-enriched GM12371 lncRNA is a prolific transcriptional regulator and is critical for synapse function in hippocampal neurons [16].

New Perspectives on RNA Function and Local Translation in Neurons

Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes.

The Role of RNA Binding Proteins for Local mRNA Translation

RNP complexes have various functions in gene expression including messenger RNA (mRNA) trafficking, RNA processing and silencing. In neurons, RBPs deliver ...

Neuronal RNA Granules: Movers and Makers - Cell Press

Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than ...

Emerging Roles of Non-Coding RNA in Neuronal Function and ...

This chapter will focus on two classes of ncRNA, miRNA and tsRNA, which are highly enriched in the central nervous system (CNS) with important roles in ...

RNA and neuronal function: the importance of post-transcriptional ...

... RNA metabolism and, consequently, brain function. This vast regulatory ... RNA and neuronal function: the importance of post-transcriptional regulation.

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian ...

Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the functional output of many important neuronally expressed genes. The ...

RNA binding proteins: a common denominator of neuronal function ...

Within the nervous system, the role of RBPs in brain function turns out to be essential due to the architectural complexity of neurons ...

Neuronal and Glial Communication via Non-Coding RNAs - MDPI

EVs are also enriched in non-coding RNAs (e.g., microRNAs, lncRNAs, and circRNA), which were formerly considered as cell-intrinsic regulators of CNS functions ...

Regulation of neuronal RNA signatures by ELAV/Hu proteins

The recent identification of ELAV's direct RNA targets revealed the protein's central role in shaping the neuronal transcriptome, and ...

RNA-binding proteins balance brain function in health and disease

This review summarizes our current understanding of the complex network of RNA-binding proteins and how they balance neuronal transmission and synaptic ...

Messenger RNAs localized to distal projections of human stem cell ...

Local translation within the axons and dendrites of neurons is involved in multiple neuronal functions, including axon maintenance, guidance, ...

The function of RNA-binding proteins at the synapse

The regulation of local protein synthesis is particularly interesting because it allows neurons to rapidly modulate the production of proteins ...

A dopamine-induced gene expression signature regulates neuronal ...

Here, we leveraged single-nucleus RNA-sequencing to generate a comprehensive molecular atlas of cell subtypes in the NAc, defining both sex- ...

iCLIP identifies novel roles for SAFB1 in regulating RNA processing ...

To investigate the functional role of SAFB1 and to identify interactions with individual RNAs in neuronal cells, we used individual-nucleotide ...