Rab gtpases
Rab GTPases as coordinators of vesicle traffic - Nature
Rab GTPases control intracellular vesicle traffic by acting as regulatable switches that recruit effector molecules when in their GTP-bound ...
Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. ... Rab GTPases regulate many ...
Rab family of small GTPases: an updated view on their regulation ...
The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of ...
Rab Family of GTPases - PMC - NCBI
There is significant expansion of the Rab family in mammalian cells to accommodate increasing complexity of the intracellular trafficking system, with 66 Rab ...
Rab Protein - an overview | ScienceDirect Topics
Rab proteins are monomeric small guanine triphosphatases (GTPases) that function as key regulators of eukaryotic membrane trafficking. Specifically, they have ...
What are Rab GTPases? - Mechanobiology Institute
Rab GTPases are the primary regulators of the vesicular trafficking pathways that are responsible for transporting the vast array of cellular ...
Comprehensive knockout analysis of the Rab family GTPases in ...
The Rab family of small GTPases comprises the largest number of proteins (∼60 in mammals) among the regulators of intracellular membrane ...
Rab Protein - an overview | ScienceDirect Topics
Rab proteins are a family of small GTPases that function as molecular switches of intracellular vesicle formation and membrane trafficking. As a key factor, Rab ...
Rab GTPases: master regulators that establish the secretory and ...
Novick discovered that the order (and thus polarity) of Rab GTPases along the secretory and endocytic pathways are established by their specific ...
Rab GTPases and phosphoinositides fine-tune SNAREs dependent ...
Here, we show that targeting of SNARE-containing liposomes is refined upon inclusion of polyphosphoinositides and Rab5. ... Our data reveal a ...
Cellular functions of Rab GTPases at a glance
ABSTRACT. Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a GTP-dependent ...
Systematic functional analysis of rab GTPases reveals limits ... - eLife
The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function ...
Rab GTPases: Central Coordinators of Membrane Trafficking in ...
Rab GTPases, which, through coordinated and dynamic intracellular membrane trafficking alongside cytoskeletal pathways, determine the ...
Rab GTPases: Switching to Human Diseases - MDPI
Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been ...
Full article: Rab GTPases and their interacting protein partners
Rabs work as typical Ras-like small GTPases. They are nucleotide dependent molecular switches that are ON in the GTP-bound (active) form and OFF in the GDP- ...
Rab GTPases and membrane identity: Causal or inconsequential?
Rab GTPases regulate membrane tethering and vesicle fusion. Eukaryotic cells are defined in part by their complex membrane organelles. This ...
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Rab GTPases: Methods and Protocols - SpringerLink
Cutting-edge and comprehensive, Rab GTPases: Methods and Protocols, Second Edition is a valuable resource for scientists working in the fields of Rab and other ...
Rab GTPases, Directors of Vesicle Docking
Transport vesicles carry Rabs in their active, GTP-bound conformations. Active Rabs recruit specific docking factors from the cytosol. We propose that the ...
Role of Rab GTPases in Membrane Traffic and Cell Physiology
The GTP-bound Rab interacts with effector proteins that mediate membrane traffic in the pathway regulated by its associated Rab. The Rab then interacts with its ...