Rab27a and Rab27b control different steps of the exosome ...

Rab27a and Rab27b control different steps of the exosome ... - Nature

Exosome biogenesis is poorly understood. The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion ...

Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs).

1 Rab27a and Rab27b control different steps of the exosome ...

Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs).

Rab27a and Rab27b control different steps of the exosome ...

50 References · The exosome pathway in K562 cells is regulated by Rab11. · Rab27b Regulates Mast Cell Granule Dynamics and Secretion · A Family of Rab27-binding ...

Rab27a and Rab27b control different steps of the exosome ...

Rab27a and Rab27b control different steps of the exosome secretion pathway. / Ostrowski, Matias; Carmo, Nuno B.; Krumeich, Sophie et al. In: Nature Cell Biology ...

Rab27a and Rab27b control different steps of the - ProQuest

Rab27a and Rab27b control different steps of the exosome secretion pathway ... You might have access to the full article... Try and log in through your ...

Rab27a and Rab27b control different steps of the exosome ...

... Rab GTPases regulate vesicle trafficking and membrane fusion events in cells, including exosomes release [11]. Among the many Rab GTPases, Rab27a has been ...

1 Rab 27 a and Rab 27 b control different steps of the exosome ...

A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a leading cause of cell death in women, and the use ...

(PDF) Rab27a and Rab27b control different steps of the exosome ...

Because Rab family guanosine triphosphatases (GTPases) together with their regulators are important membrane trafficking organizers, we investigated which Rab ...

RAB27B controls palmitoylation-dependent NRAS trafficking and ...

Although RAB27A and RAB27B share similar functions, they also can be involved in different vesicles and different cell types, or can have ...

Rab27a and Rab27b control different steps of the exosome ...

Find Rab27a and Rab27b control different steps of the exosome secretion pathway. The Institut Curie is the leading center for research and ...

Rab27b, a Regulator of Exosome Secretion, Is Associated With ...

Rab27a and Rab27b regulate exocytosis of multivesicular endosomes and control different steps of the exosome secretion pathway (46-48). Rab27a likely has a ...

KIBRA controls exosome secretion via inhibiting the proteasomal ...

Rab27a and Rab27b share a common function in MVB docking to the PM but the two Rab27 isoforms have different roles in the exosomal pathway.

Rab27a Supports Exosome-Dependent and -Independent ...

We have recently shown that the small GTPases RAB27A and RAB27B are critically required for exosome secretion by HeLa cells (13). RAB27A/B are known to control ...

Rab27b, a Regulator of Exosome Secretion, Is Associated With ...

Rab27a and Rab27b knockdown suppressed exosome secretion in gastric cancer cells. ... Rab27b control different steps of the exosome secretion pathway. Nat Cell ...

Rab7a and Rab27b control secretion of endothelial microRNA ...

With respect to vesicular secretion, Rab11, Rab27a/27b, and Rab35 were found to be essential for exosomal release in different cell lines [12], ...

Functional implications of Rab27 GTPases in Cancer

Recent studies have revealed that Rab27A and Rab27B control exosome secretion in various cell types, including dendritic cells [22], cervical ...

Vesicular Trafficking, a Mechanism Controlled by Cascade ... - MDPI

Rab35 has also been reported to be involved in exosome secretion in hepatocellular carcinoma [54] and in the fusion steps of MVB to PM [51]. A recent study ...

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

However, recent evidence has indicated that by interacting with different Rab27 effectors Rab27A and Rab27B play different roles in special ...

RAB27A - an overview | ScienceDirect Topics

The central role of RAB27 in exosomal secretion has been widely confirmed30–32 and hence this RAB protein is currently the subject of intense investigation.