Rapid generation of gene|targeted EPS|derived mouse models ...

Rapid generation of gene-targeted EPS-derived mouse models ...

One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem (ES) cells, which is used to produce ...

Rapid generation of gene-targeted EPS-derived mouse models ...

Because complete pluripotent cell-derived mice can be directly obtained through tetraploid complementation, this method bypasses the requirement of mouse ...

Rapid generation of gene-targeted EPS-derived mouse models ...

Based on gene targeting in mouse EPS cells, we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid ...

Rapid generation of gene-targeted EPS-derived mouse models ...

Based on gene targeting in mouse EPS cells, we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid ...

Rapid generation of gene-targeted EPS-derived mouse models ...

Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. by Haibo Li, Chaoran Zhao, Jun Xu, Yaxing Xu, Chunmei Cheng, ...

[PDF] Rapid generation of gene-targeted EPS-derived mouse ...

DOI:10.1007/s13238-018-0556-1; Corpus ID: 256065136. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation.

Rapid generation of gene-targeted EPS-derived mouse models ...

Based on gene targeting in mouse EPS cells, we established a new approach to directly and rapidly generate gene-targeted mouse models through ...

Rapid generation of gene-targeted EPS-derived mouse models ...

Article on Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation, published in Protein & cell 10 on 2018-06-13 by ...

Extended pluripotent stem cells facilitate mouse model generation

These results showed that gene targeting in mouse EPS cells combined with tetraploid complementation (Nagy et al., 1993) can efficiently produce ...

Rapid target gene validation in complex cancer mouse models ...

The GEMM‐ESC approach describes and validates an improved method for generating mouse cancer models directly from embryonic stem cells. This technology speeds ...

Rapid Generation of Somatic Mouse Mosaics with Locus-Specific ...

Because generating these mouse models is an expensive and laborious process, alternative transgenic approaches, such as gene delivery by ...

Generating mouse models for biomedical research: technological ...

This strategy has been used effectively to enable the rapid and high-throughput production of thousands of gene knockouts in mouse ES cells in ...

Efficient and Fast Generation of Relevant Disease Mouse Models by ...

Knockout mice for human disease-causing genes provide valuable models in which new therapeutic approaches can be tested.

targeted mouse mutants, from vector design to phenotype analysis

It has become feasible to produce mice with designed genetic alterations ranging from simple gene disruptions and point mutations to large genomic deletions ...

Rapid generation of inducible mouse mutants - Oxford Academic

An ES cell line, was established that carries the inducible recombinase and a loxP ‐flanked lacZ reporter gene. Out of this line, completely ES cell‐derived ...

Nomenclature | Genetically Engineered & Mutant Mice

Targeted mutant mice are produced by first inducing gene disruptions, replacements or duplications into embryonic stem (ES) cells via homologous recombination ...

TurboKnockout ® Gene Targeting Mice - Cyagen

... mouse models as fast as 6-8 months. This proprietary gene targeting ... derived ESCs suitable for generating targeted genetic models. Significance ...

Efficient generation of mouse models of human diseases via ABE

To exclude any possible phenotype-associated non-target mutations beyond the editing window, we sequenced 500 bp target-flanking genomic region ...

Model Generation Services (MGS) | The Jackson Laboratory

Both global and conditional knock-out models are typically made using CRISPR/Cas9 in either mouse zygotes or ES cells, on the genetic background of your choice.

Transgenic Mouse Models in Cancer Research - Frontiers

Generation of general and tissue-specific gene ... Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models.