Re|evaluating the role of dacarbazine in metastatic melanoma

Re-evaluating the role of dacarbazine in metastatic melanoma

Since dacarbazine was approved for treating metastatic melanoma in the 1970s, numerous studies have evaluated whether different schedules and ...

Re-evaluating the role of dacarbazine in metastatic melanoma

Since the original approval of dacarbazine for the treatment of metastatic malignant melanoma, considerable effort has been expended in attempts to improve ...

Re-evaluating the role of dacarbazine in metastatic melanoma

Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years? ... Systematic review of medical treatment in melanoma ...

Re-evaluating the role of dacarbazine in metastatic melanoma

Request PDF | Re-evaluating the role of dacarbazine in metastatic melanoma: What have we learned in 30 years ... Metastatic Malignant Melanoma. Article. Feb ...

Dacarbazine Combined Targeted Therapy versus Dacarbazine ...

Malignant melanoma is the most aggressive and deadly form of skin cancer. Dacarbazine (DTIC) has been the approved first-line treatment for ...

Impact of prior treatment with immune checkpoint inhibitors ... - Nature

Our study found a significantly better PFS from Day 1 of dacarbazine treatment in advanced melanoma patients without brain metastasis previously ...

Treatment of Metastatic Malignant Melanoma with Dacarbazine plus ...

We randomly assigned 117 patients with metastatic malignant melanoma to treatment with dacarbazine alone or dacarbazine in combination with ...

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic ...

We conducted a phase 3 study of ipilimumab (10 mg per kilogram) plus dacarbazine in patients with previously untreated metastatic melanoma.

Phase I–II study of plitidepsin and dacarbazine as first-line therapy ...

Mouawad R, Sebert M, Michels J, Bloch J, Spano JP, Khayat D (2010) Treatment for metastatic malignant melanoma: old drugs and new strategies.

Chemotherapy in Cutaneous Melanoma: Is There Still a Role?

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin ...

Evaluation of paclitaxel and dacarbazine combination in metastatic ...

Background: Metastatic melanoma has a poor prognosis, with less than 11 months median survival rate from the diagnosis of distant metastasis.

337-Melanoma metastatic dacarbazine SUPERSEDED - eviQ

Treatment was repeated every 3 weeks. Patients were observed for tumour response, survival time, and toxicity. Median survival time from randomization was 7 ...

A randomized, controlled phase III trial of nab-Paclitaxel versus ...

Phase 3 study of docosahexaenoic acid-paclitaxel versus dacarbazine in patients with metastatic malignant melanoma ... treatment efficacy: re-analysis of GM301 ...

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic ...

Patients were ineligible if they had re- ceived any prior treatment for metastatic disease. Patients who received prior adjuvant therapy were.

Chemotherapy for metastatic melanoma - Gogas - 2007 - Cancer

DTIC remains the only currently used cytotoxic drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic ...

Interaction of Dacarbazine and Imexon, In Vitro and In Vivo, in ...

Dacarbazine (DTIC) is a commonly used chemotherapeutic agent for the treatment of advanced stage metastatic melanoma (2), although response rates are low. Many ...

Dacarbazine-Loaded Targeted Polymeric Nanoparticles for ...

Overall, this research provided multi-functional NPs, which endow a new option for the treatment of MM. Introduction. Malignant melanoma (MM) is ...

Medline ® Abstract for Reference 48 of 'Systemic treatment of ...

Medline ® Abstract for Reference 48 of 'Systemic treatment of metastatic melanoma lacking a BRAF mutation' ... BACKGROUND Nivolumab was associated with higher ...

Which drug, and when, for patients with BRAF-mutant melanoma?

Agarwala, SS ∙ Kirkwood, J ∙ Gore, M ∙ et al. Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase 2 study. J Clin ...

Chemotherapy for advanced melanoma - Cancer Research UK

You usually have dacarbazine every few weeks. The time between one round of treatment and the start of the next is called a cycle. You usually have chemotherapy ...