Recent advances in human stem cell|based modeling of Tuberous ...

Recent advances in human stem cell-based modeling of Tuberous ...

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by epilepsy, intellectual disability, and benign tumors of ...

New frontiers in modeling Tuberous Sclerosis with human stem cell ...

Recent advances in human stem cell and genome engineering have enabled the generation of genetically-defined human cellular models for brain disorders. These ...

Recent advances in human stem cell-based modeling of Tuberous ...

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by epilepsy, intellectual disability, and benign tumors of the brain, ...

Recent advances in human stem cell-based modeling of Tuberous ...

The remarkable capacity of these cells to be used as a model for TSC in two- and three-dimensional cultures is discussed, the potential variability in iPSC ...

Recent advances in human stem cell-based modeling of Tuberous ...

Recent advances in stem cell biology with the derivation of human-induced pluripotent stem cells (hiPSCs) from somatic cells from patients have opened new ...

Recent advances in human stem cell-based modeling of Tuberous ...

PDF | Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by epilepsy, intellectual disability, and benign tumors of the.

New frontiers in modeling tuberous sclerosis with human stem cell ...

Here we discuss recent progress in human stem cell-based modeling of TSC and highlight challenges and opportunities for further efforts in this area.

Recent advances in human stem cell-based modeling of Tuberous ...

This page is a summary of: Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex , Molecular Autism, February 2020, ...

Human pluripotent stem cell modeling of tuberous sclerosis complex ...

We report the first model of multi-system TSC cell types, characterized by NPCs and neural crest cells (NCCs) differentiated in parallel from multiple ...

New frontiers in modeling tuberous sclerosis with human stem cell ...

Recent advances in human stem cell and genome engineering have enabled the generation of genetically defined human cellular models for brain disorders.

2018 Tuberous Sclerosis Complex Highlight - Modeling TSC and ...

2017. Human pluripotent stem cell-derived TSC2-haploinsufficient smooth muscle cells recapitulate features of Lymphangioleiomyomatosis. Cancer ...

New frontiers in modeling Tuberous Sclerosis with human stem cell ...

Here we discuss recent progress in human stem cell‐based modeling of TSC and highlight challenges and opportunities for further efforts in this ...

Recent advances in human stem cell-based modeling of Tuberous ...

Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex. Molecular autism, 2020-02, Vol.11 (1), p.16-8, Article 16 [Peer Reviewed ...

Advances in the genetics and neuropathology of tuberous sclerosis ...

Recent advances in human stem cell-based modeling of tuberous sclerosis complex ... human astrocytes and SEGA-derived cell cultures. Glia. 2016; 64:1066 ...

The power of human stem cell-based systems in the study of ...

Therefore, stem cell-based models advance our understanding of human brain development by revealing human-specific mechanisms contributing to the broad ...

Human cerebral organoids — a new tool for clinical neurology ...

Organoids are 3D human cell culture models that originate from pluripotent stem cells and recapitulate the hallmarks of human neurodevelopment, ...

Renal organoid modeling of tuberous sclerosis complex reveals ...

Time course single-cell RNA sequencing demonstrates that loss of TSC1 or TSC2 affects multiple developmental processes in the renal epithelial, ...

High glucose concentrations mask cellular phenotypes in a stem cell ...

Animal models of TSC insufficiently capture the neurodevelopmental biology of cortical tubers, and hence, human stem cell-based in vitro models ...

Building on a Solid Foundation: Adding Relevance and ... - Frontiers

Our principal focus is on advances in engineering neural cells and tissue constructs from human pluripotent stem cells (PSCs), though primary human cell and ...

Human Pluripotent Stem Cell Modeling of Tuberous Sclerosis ...

We report the first model of multi-system TSC cell types, characterized by NPCs and neural crest cells (NCCs) differentiated in parallel from multiple ...