Recent advances in targeted protein degraders as potential ...

Targeted protein degradation (TPD) technology has gradually become widespread in the past 20 years, which greatly boosts the development of ...

Recent advances in targeted protein degraders as potential ... - NCBI

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat Struct Mol Biol. 2020;27:605–614.

New therapies on the horizon: Targeted protein degradation in ...

Because of the potential of TPD to decrease the levels of specific disease-associated proteins, it is a revolutionary small-molecule-based ...

Targeted protein degradation: advances in drug discovery and ...

Their smaller size and simplicity offer advantages such as better cellular permeability and potential oral administration. However, designing ...

Developing New Methods for Targeted Protein Degradation

“This targeted protein degradation (TPD) strategy can convert inactive protein-binding small molecules into active protein degraders and also ...

Recent advances in targeted protein degraders as potential ...

Contrary to small inhibitors that act on protein kinases, transcription factors, ion channels, and other targets they can bind to, targeted protein degraders ...

PROTAC protein degraders to drug the undruggable enter phase 3 ...

Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological ...

Recent advances in targeted protein degradation research in cancer

With TPD's catalytic efficiency, each agent can repeatedly target and degrade multiple protein copies, setting a new standard in cancer treatment efficacy.

Recent advancements in targeted protein knockdown technologies ...

Among the TPD approaches, proteolysis targeting chimeras (PROTACs) have emerged as one of the most promising approaches for the selective elimination of ...

Targeted protein degradation: current molecular targets, localization ...

This evolution extends the potential of TPD to various diseases. Notably, TPD can target proteins at demanding locations, such as the extracellular matrix (ECM) ...

Recent advances in targeted protein degraders as potential ...

... Targeted protein degradation (TPD) is a pioneering approach for developing speci c degraders that target the proteins of interest (POIs) (17) ...

Clinical Translation of Targeted Protein Degraders - Kong - 2023

Targeted protein degradation (TPD) has emerged as a potentially transformational therapeutic modality with considerable promise.

Accelerating Targeted Protein Degradation Research with AI and ...

Targeted protein degradation was already having its own renaissance, with the advancement of numerous degraders to clinical development over the ...

The emerging role of targeted protein degradation to treat and study ...

PROTACs targeting BTK are in development, including CRBN-based NX-2127, which demonstrated efficacious BTK degradation across multiple B-cell ...

Recent advances in the molecular design and applications of ...

Among the protein degradation-based multi-specific approaches, proteolysis targeting chimera (PROTAC) is the main strategy applied in the ...

New drug reveals a key mechanism to overcome resistance to ...

Protein degraders offer a novel approach to targeting undruggable diseases by hijacking the cell's degradation machinery. · Scientists at IRB ...

Induced protein degradation for therapeutics: past, present, and future

Heterobifunctional degraders chemically link a compound that binds a ubiquitin ligase and another that binds a target protein, which effectively ...

Targeted protein degradation & next-generation ... - BMG Labtech

Both types of degraders use the ubiquitin-proteasome system to achieve targeted protein degradation (Fig. 2). However, inspired by progress with ...

Targeted Protein Degradation: Advances, Challenges, and ...

Targeted protein degradation necessitates a novel approach to small molecule drug discovery, shifting from static structures that function ...

Beyond canonical PROTAC: biological targeted protein degradation ...

... protein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significant advancement in recent years ...