Recent advances in the mechanisms of NLRP3 inflammasome ...

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of ...

Mechanisms of inflammasome activation: recent advances and ...

NLRs such as NLRP1b, NLRP3 and NLRC4 as well as the ALR, AIM2, constitute the most well characterized inflammasomes (Fig. 1) [2]. Among these, NLRP3 is still ...

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

During cellular stress responses, stress granules are critical to cell survival. A recent study showed that the stress granule protein DEAD-box ...

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Current treatment options consist of IL-1 inhibitors, however, the development of inhibitors that target the NLRP3 inflammasome is of great interest for these ...

Mechanisms of NLRP3 inflammasome activation and the ...

Upon activation, NLRP3 inflammasome initiates the release of inflammatory cytokines and triggers a form of cell death known as pyroptosis. Dysregulation or ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

In this review, we summarize current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly targetNLRP3 are ...

Recent advances in the NEK7-licensed NLRP3 inflammasome ...

In this review, we firstly describe the cellular/molecular mechanisms of the NEK7-licensed NLRP3 inflammasome activation. Then we detail the potential ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory ...

Recent Advances of the NLRP3 Inflammasome in Central Nervous ...

The NLRP3 inflammasome plays a pathogenic role in neuroinflammatory diseases. Here, we review described mechanisms that have been proposed to be ...

New Insights on NLRP3 Inflammasome: Mechanisms of Activation ...

Inflammasome-mediated neuroinflammation may influence neural development, by generating inflammatory mediators that affect neurogenesis, ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Understanding the mechanisms of NLRP3 activation will enable the development of its specific inhibitors to treat NLRP3-related diseases. In this review, we ...

Mechanism of NLRP3 inflammasome activation and its role in ...

The assembly of NLRP3 inflammasome promotes the maturation of interleukin-1beta (IL-1β) and IL-18 mediated by caspase-1 in microglia, which ...

Mechanism and Regulation of NLRP3 Inflammasome Activation

The NLRP3 inflammasome is an essential mediator of host immune responses through the activation of caspase-1 and interleukin 1 beta (IL-1β)/IL-18.

The mechanism of NLRP3 inflammasome activation and its ...

Thus, NLRP3 is an important therapeutic target, and researchers are putting a lot of effort into developing its inhibitors. The review summarizes the latest ...

NLRP inflammasomes in health and disease | Molecular Biomedicine

Here, we provide the latest research progress on NLRP inflammasomes, including NLRP1, CARD8, NLRP3, NLRP6, NLRP7, NLRP2, NLRP9, NLRP10, and ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ... - MDPI

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines.

Mechanism of NLRP3 inflammasome activation - Sutterwala - 2014

The initial inflammasome priming step upstream of activation affects NLRP3 at the transcriptional level and also serves to trigger ...

Recent Advances of the NLRP3 Inflammasome in - ProQuest

The exact molecular mechanisms on the assembly, activation, and regulation of NLRP3 inflammasome are required to be further examined, which are very important ...