Recent advances in understanding the pathogenesis of Huntington's ...

Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder that is characterized by abnormal involuntary movements (chorea), ...

Recent advances on the pathogenesis of Huntington's disease

We review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG ...

Editorial: New insight into Huntington's disease - Frontiers

Among these disorders, Huntington's disease is the most studied, allowing us to understand its neuropathology better and bringing us closer to a possible ...

Review of Huntington's Disease: From Basics to Advances in ...

There has been tremendous progress regarding disease pathogenesis, clinical management and promising new therapeutic avenues including disease- ...

Recent approaches on Huntington's disease (Review)

Different compounds may be candidates for the treatment of neurodegenerative disorders, including HD. A recent study proposed the utilization of ...

Huntington Disease: Mechanism of Pathogenesis and Recent ...

Although, the N-terminal fragments of mutant huntingtin (mHtt) misfolded into amyloid-like fibrils as a key signature of HD pathology. Currently, no effective ...

Huntington's Disease: Complex Pathogenesis and Therapeutic ...

Recent advances in understanding the molecular mechanisms of HD, coupled with the development of gene therapies and other emerging therapeutic approaches ...

Study addresses multiple challenges of the pathogenesis of ...

Recent genetic data from patients with Huntington's disease (HD) show that DNA repair is an important factor that determines how early or ...

A Review of 150 Years of Huntington's Disease Research - MDPI

Despite the identification and characterisation of the causative gene and mutation and significant advances in our understanding of the cellular pathology in ...

Huntington's Disease: Recent Advances in Diagnosis and ...

Huntington's Disease (HD) is a progressive degenerative disorder of the central nervous system inherited as an autosomal dominant trait.

Huntington's Disease News - ScienceDaily

13, 2024 — The Huntington's disease (HD) mutation eventually causes a fatal brain disease in adulthood, but a new study finds that early in life, children with ...

Huntingtin and the molecular pathogenesis of Huntington's disease

Evidence is focused on that supports a role for transcriptional dysfunction and impaired protein folding and degradation as early events in disease ...

Huntingtin and the molecular pathogenesis of Huntington's disease

Huntington's disease (HD) is a late‐onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene.

Huntington's disease: MedlinePlus Genetics

Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning new ...

Huntington's disease: Molecular basis of pathology and status of ...

Mutations in huntingtin (HTT) protein, which is essential for neuronal development, lead to the development of HD. An increase in the number of ...

Huntington disease: new insights into molecular pathogenesis and ...

before introducing the latest developments in our understanding of disease pathogenesis in the sections. 73 that follow. In individuals with HD, the expanded ...

[PDF] Huntington's disease: from pathology and genetics to potential ...

Not all of the effects of mutant huntingtin may be cell-autonomous, and it is possible that abnormalities in neighbouring neurons and glia may also have an ...

Recent advances in Huntington's disease - Lippincott

Recent advances in the understanding of the molecular biology and pathophysiology of Huntington's ... pathogenesis of the disease, and raise the very ...

Spotlight on Recent Advances in Huntington Disease

Target Audience and Goal Statement · Have increased knowledge regarding the. Recognition of chorea in HD; Clinical data for pharmacotherapies for ...

Huntington disease update: new insights into the role of repeat ...

... to understand the pathogenesis of HD as precisely as possible. In addition to the long-postulated toxicity of the polyglutamine-expanded ...