Recommendations for designing and analysing multi|arm non ...

Recommendations for designing and analysing multi-arm non ...

Abstract. Background and purpose: Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental ...

Recommendations for designing and analysing multi-arm non ...

Trials should consider the recommendations in this paper and ensure they clearly define and reason their choices of trial design and analysis techniques.

(PDF) Recommendations for designing and analysing multi-arm non ...

PDF | Background and purpose Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental ...

Recommendations for designing and analysing multi-arm ... - Ex Libris

Abstract Background and purpose Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental treatment arms, ...

a review of methodology and current practice | Trials | Full Text

Recommendations for designing and analysing multi-arm non-inferiority trials: a review of methodology and current practice · Access & Citations · Online attention.

(PDF) Recommendations for designing and analysing multi-arm non ...

First looking at statistical issues that may arise when carrying out MANI trials and outlining potential way to account for these issues before ...

Recommendations for designing and analysing multi-arm non ...

Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental treatment arms, can be useful in ...

Recommendations for designing and analysing multi-arm non ...

To maintain the statistical integrity of such trials, issues regarding both design and analysis must be considered, from both the multi-arm and ...

Non-adjustment for multiple testing in multi-arm trials of distinct ...

Multi-arm trial designs that utilise a common control group are also associated with an increased risk of multiple false-positive errors; that is, the ...

Planning and Analyzing a Group-Sequential Multi-Arm Multi-Stage ...

This document provides an example of implementing, simulating and analyzing multi-arm-multi-stage (MAMS) designs for testing rates with ...

Design of a multi-arm randomized clinical trial with no control arm

The algorithm allows poorly-performing arms to be dropped during interim analyses. Consequently, the study may be completed earlier than planned. We used ...

Advantages of multi-arm non-randomised sequentially allocated ...

The MASTER design recruits patients to one arm at a time, pausing recruitment to an arm when it has recruited the required number for an interim ...

Multi-Arm Non-Inferiority Tests for Treatment and Control Means in a ...

In this multi-arm design, there are G treatment groups and one control group. A ... Design and Analysis of Cluster Randomization Trials in Health Research.

Multi-arm multi-stage designs (MAMS) - GitHub Pages

Only simulates test statistics (not patients) for T2E. No seed can be set for simulations. rpact: Flexible simulation and analysis functions.

Multi-Arm Multi-Stage (MAMS) - PANDA

MAMS clinical trials compare several active treatment arms, often to a single, shared control arm. MAMS trials use one or several interim analyses to assess ...

Design, analysis and reporting of multi-arm trials and strategies to ...

The remaining 17 of 45 (38%) trial protocols did not state how or why they would not control the FWER in the context of multiple comparisons.

Reporting of Multi-Arm Parallel-Group Randomized Trials: Extension ...

Multi-arm trials that use a parallel-group design (comparing treatments by concurrently randomizing participants to one of the treatment groups, ...

Some recommendations for multi-arm multi-stage trials

Multi-arm multi-stage designs can improve the efficiency of the drug-development process by evaluating multiple experimental arms against a common control ...

Inclusion of non-inferiority analysis in superiority-based clinical trials ...

2.3. Simulations. A total of 12,768 two-stage, single-arm designs were computed based on different assumptions of p0, p1 ...

Multi-Arm Multi-Stage (MAMS) - PANDA - University of Sheffield

Some MAMS designs may include stopping rules at an interim analysis beyond stopping as a consequence of treatment selection (e.g., when no promising treatment ...