Recommendations on multiple testing adjustment in multi|arm trials ...

Recommendations on multiple testing adjustment in multi-arm trials ...

Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency advantages over independent trials ...

Recommendations on multiple testing adjustment in multi-arm trials ...

Abstract. Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency.

Multiplicity adjustments in parallel-group multi-arm trials sharing a ...

We propose that adjustment should not be a requirement in multi-arm, parallel-group trials testing distinct treatments and sharing a control group.

Correcting for multiple-testing in multi-arm trials: is it necessary and ...

A multiple-testing procedure is a statistical method of adjusting the significance level used for testing each hypothesis so that the chance of ...

Recommendations on multiple-testing adjustment in multi-arm trials ...

Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency advantages over independent trials ...

Recommendations for designing and analysing multi-arm non ...

While it is possible to adjust for multiple testing within the setup of the trial hypotheses, it may not always be practical or within the frame ...

An introduction to multiplicity issues in clinical trials - Oxford Academic

However, there is currently no consensus on the need for multiplicity adjustment in a multi-arm trial with distinct treatment arms, according to ...

Points to consider on multiplicity issues in clinical trials

with this is recommended. This document discusses situations with relevance for multiple testing in clinical trials and commonly practised and acknowledged ...

Recommendations on multiple-testing adjustment in multi-arm trials ...

For competing experimental therapies, the correlation between hypotheses can be advantageous as it eliminates bias due to the experimental ...

Reporting of Multi-Arm Parallel-Group Randomized Trials: Extension ...

Multi-arm randomized clinical trials have several forms but are typically a combination of elements, including multiple active interventions, ...

Correcting for multiple-testing in multi-arm trials: is it necessary and ...

Currently, there are conflicting opinions on whether a multiple-test correction is needed for multi-arm trials. Our opinion is that stringent multiple-testing ...

Controlling type I error rates in multi‐arm clinical trials: A case for the ...

Testing several experimental treatments within a single multi-arm trial is one way to dramatically increase the efficiency of drug development.

Multiple Endpoints in Clinical Trials | FDA

The purpose of this guidance is to describe various strategies for grouping and ordering endpoints for analysis and applying some well- ...

Use and misuse of corrections for multiple testing - ScienceDirect

False discovery rate control is a recommended alternative to Bonferroni-type adjustments ... Non-adjustment for multiple testing in multi-arm trials of distinct ...

(PDF) Non-adjustment for multiple testing in multi-arm trials of ...

There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments.

Non-adjustment for multiple testing in multi-arm trials of distinct ...

It is therefore recommended to control the. FWER in this situation so that the probability of incor- rectly concluding that the treatment is effective is below.

Multiple Endpoints in Clinical Trials Guidance for Industry | FDA

Among these are adjustments to the. 289 alpha level for determining that an individual endpoint test is positive, structuring the order in. 290 which the ...

On the need to adjust for multiplicity in confirmatory clinical trials with ...

... multi-arm comparisons of several drugs within each sub-study. An ... Recommendations on multiple adjustment in multi-arm trials with a shared control group.

Practical Guidelines for Multiplicity Adjustment in Clinical Trials

It is well recognized by public health researchers today that performing multiple comparisons with a per-comparison rate of 0.05 can substantially inflate the ...

Design, analysis and reporting of multi-arm trials and strategies to ...

Recommendations on multiple testing adjustment in multi-arm trials with a shared control group. Stat Methods Med Res 2018;. 27:1513–30. 15 ...