Regeneration and rejuvenation of skin by a topical YAP activator

They find that transient pharmacological YAP activation induces a reversible, proproliferative transcriptional program in both the epidermis and ...

Regeneration and rejuvenation of skin by a topical YAP activator.

Regeneration and rejuvenation of skin by a topical YAP activator

Pharmacological YAP activation promotes regenerative repair of cutaneous wounds. Proc. Natl. Acad. Sci. USA, in press.

Regeneration and rejuvenation of skin by a topical YAP activator

Regeneration and rejuvenation of skin by a topical YAP activator-article.

Regeneration and rejuvenation of skin by a topical YAP activator

It consists of the application of one or more chemical exfoliating compounds to the skin in order to destruct first and then regenerate part of epidermis and ...

Pharmacological YAP activation promotes regenerative repair of ...

Here, we report that topical application of PY-60, a small-molecule activator ... Skin / injuries; Swine; Wound Healing* / physiology. Grants ...

Pharmacological YAP activation promotes regenerative repair of ...

These results demonstrate that transient topical administration of a YAP activating agent may represent a generalizable therapeutic approach to treating ...

Pharmacological YAP activation promotes regenerative repair of ...

A comment on this article appears in "Regeneration and rejuvenation of skin by a topical YAP activator." Proc Natl Acad Sci U S A. 2023 Aug ...

Pharmacological YAP activation promotes regenerative repair of ...

Here, we report that topical application of PY-60, a small-molecule activator of the ... Boosting Skin Wound Healing by Agrin-Mediated YAP/TAZ Activation.

New route to targeting the Hippo pathway - Nature

Furthermore, when applied topically to the dorsal skin of wild-type mice over the course of 10 days, PY-60 promoted a dramatic YAP-dependent ...

YAP and TAZ Regulate Skin Wound Healing - ScienceDirect.com

YAP and TAZ also modulate the expression of TGF-β1 signaling pathway components such as Smad-2, p21, and Smad-7. These results suggest that YAP and TAZ ...

YAP/TAZ Drive Agrin–Matrix Metalloproteinase 12–Mediated ...

RNA-sequencing analysis revealed that in addition to a disorganized extracellular matrix, agrin-depleted skin cells have impaired YAP/TAZ ...

Integrin signalling regulates YAP and TAZ to control skin homeostasis

The Yes-associated protein (YAP) family of transcriptional co- activators are emerging as potent oncoproteins that strongly drive cell proliferation in many ...

Recent advances in the role of Yes‐associated protein in dermatosis

YAP plays an important role in skin wound repair. YAP was shown to be upregulated in the basal cell layer of injured skin and localized in the ...

The common YAP activation mediates corneal epithelial ... - Nature

The rapid activation of YAP at the margin at 8 h pw during regeneration implies that wound could activate YAP of surrounding corneal epithelial ...

Optogenetic control of YAP can enhance the rate of wound healing

During regeneration, there are two main mechanisms for repair: (i) migration of newly proliferated cells into the injured area; and (ii) cell ...

The Roles of YAP/TAZ and the Hippo Pathway in Healthy ... - MDPI

Expression of YAP and TAZ in Skin during Development, Homeostasis, Regeneration and Cancer ... Their widespread activation in human skin cancers and their ...

Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 ...

DPPA administration during the regenerative period promotes alveolar bone regeneration. (A) Twelve-week-old males were intraperitoneally injected with BrdU, ...

Skin Regeneration and Rejuvenation - Harvard Stem Cell Institute

Understanding how to harness stem cells for scarless wound healing will also provide key insights into regenerating aged skin, a process termed rejuvenation.

Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and ...

Collagen serves as the primary structural protein in the skin, mainly produced by dermal fibroblasts. During the process of skin dermal aging, ...