Regulating the NLRP3 Inflammasome in Autoimmune Diseases

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an essential component of the human innate immune system, ...

Regulating the NLRP3 Inflammasome in Autoimmune Diseases - PMC

The priming of NLRP3 is commonly dependent on the NF-κB signaling pathway. Surface receptors, including PRRs and TNF receptor (TNFR) superfamily members, ...

Role of the NLRP3 inflammasome in autoimmune diseases

The NLRP3/IL-1 axis is essential for the inflammatory response and immune system functioning. 3. Regulation of NLRP3 inflammasome. The NLRP3 inflammasome plays ...

NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive ...

Namely, NLRP3 inflammasome might participate in the transition from innate immunity to adaptive immunity in the pathogenesis of autoimmune diseases as a ...

Review NLRP3 inflammasome and its role in autoimmune diseases

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory ...

NLRP3 inflammasome: a key player in the pathogenesis of life-style ...

The NLRP3 inflammasome is an important sensor and indicator not only of inflammatory immune disorders but also of metabolic disorders, ...

Inflammasome Molecular Insights in Autoimmune Diseases - MDPI

NLRP1, NLRP3, and NLRC4 are components of inflammatory cytoplasmic dimers. They possess a central NBD, a C-terminal leucine-rich repeat (LRR), and a pyrin or ...

The NLRP3 inflammasome: contributions to inflammation-related ...

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

More recent studies have shown that microtubule affinity regulating kinase 4 (MARK4) physically interacts with NLRP3 and drives its localization ...

Role of NLRP3 Inflammasome in Rheumatoid Arthritis - Frontiers

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Increasing evidence suggests that the NLRP3 inflammasome is involved in the ...

Role of inflammasomes in inflammatory autoimmune rheumatic ...

(D) The gene expression of NLRP3 and intracellular NLRP3 level are increased in SS compared to healthy normal control. The activation of NLRP3 ...

New Potentiality of Bioactive Substances: Regulating the NLRP3 ...

Aberrant functions of intracellular NLRP3 inflammasomes promote the occurrence and development of autoimmune diseases, with the majority of studies currently ...

The NLRP3 Inflammasome as a Pathogenic Player Showing ... - MDPI

The high ASCVD burden in RA patients [59,60] may result from a combination of traditional risk factors, disease-specific factors, chronic inflammation, genetic ...

Role of the NLRP3 inflammasome in autoimmune diseases.

Role of the NLRP3 inflammasome in autoimmune diseases. · Zhe Li, Jialong Guo, L. Bi · Published in Biomedicine & pharmacotherapy… 29 July 2020 · Medicine ...

A narrative review of positive regulation of NLRP3 inflammasome in ...

In RA chronic autoimmune diseases, inflammasome triggers innate immune defense of the host by releasing pro-inflammatory cytokines such as IL-1β ...

Role of the NLRP3 inflammasome in autoimmune diseases

Among its various functions, the NLRP3 inflammasome can induce the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 while also promoting ...

NLRP3 inflammasome and its role in autoimmune diseases - OUCI

List of references · L, Structures and functions of the inflammasome engine, J. · Kv, The NLRP3 inflammasome: molecular activation and regulation to therapeutics, ...

NLRP3 inflammasome activation mechanism and its role in ...

Recent studies show that the NLRP3 inflammasome plays an important role in regulating autoimmune liver diseases, including autoimmune hepatitis, primary biliary ...

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune ...

... regulates NLRP3 inflammasome activity and discuss the implications of this regulation on the pathogenesis of autoinflammatory and autoimmune diseases.

Role of NLRP3 inflammasome in systemic sclerosis

SSc, as an autoimmune disease featured by inflammation, vascular damage, and fibrosis, involves immune cells, endothelial cells (ECs), and ...