Regulation of inflammasomes by autophagy

Here we review recent findings regarding the involvement of autophagy in the regulation of inflammasome activation and development of inflammatory disorders. (J ...

Interplay Between NLRP3 Inflammasome and Autophagy - Frontiers

In the last decade numerous studies have further indicated that autophagy can regulate inflammasome activation, including the NLRP3 inflammasome activation, ...

Inflammasome and Autophagy Regulation: A Two-way Street - PMC

Autophagic removal of intracellular DAMPs, inflammasome components or cytokines can reduce inflammasome activation. Similarly, inflammasomes can regulate the ...

Regulation of inflammasomes by autophagy

Recent studies have shown that autophagy, an intracellular degradation system associated with maintenance of cellular homeostasis, plays a key role in ...

Regulation of Inflammasome by Autophagy - PubMed

Inflammasome is a molecular platform that mediates the activation of caspases, maturation of interleukin-1 (IL-1) family members, and leads to inflammatory ...

Regulation of inflammasomes by autophagy - ScienceDirect.com

In myeloid cells, such as macrophages, autophagy suppresses inflammasome activation by promoting elimination of hazardous material, such as damaged organelles.

Inflammasome and Autophagy Regulation: A Two-way Street

Inflammasomes can regulate the autophagic process, allowing for a two-way mutual regulation of inflammation that may hold the key for treatment of multiple ...

Targeting autophagy regulation in NLRP3 inflammasome-mediated ...

We highlight the therapeutic potential of autophagy activators in COVID-19 by inhibiting the NLRP3 inflammasome, thereby avoiding the cytokine storm.

Regulation of the NLRP3 inflammasome by autophagy and mitophagy

The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response.

Regulation of Inflammasome by Autophagy - SpringerLink

Autophagy is a fundamental and conserved degradation system in events of nutrient starvation or metabolic stress. It regulates inflammasome ...

The Role of the Effects of Autophagy on NLRP3 Inflammasome in ...

Autophagy can negatively regulate the activation of the NLRP3 inflammasome by scavenging endogenous activators of inflammasome, including ...

Interaction among inflammasome, autophagy and non-coding RNAs

Therefore, autophagy may serve as an auxiliary control measure for some infectious diseases but may not work for infections of other ...

Regulation of inflammasome signaling | Nature Immunology

Autophagy regulates IL-1β production via the removal of damaged mitochondria, which are potent sources of ROS that drive NLRP3 activation.

Full article: Autophagy balances inflammation in innate immunity

As a metabolic, cytoplasmic quality control and general homeostatic process, autophagy is primarily cytoprotective, tissue protective and anti-inflammatory. Its ...

Regulation Where Autophagy Intersects the Inflammasome

Significance: The autophagy and inflammasome pathways are ancient innate immune mechanisms for controlling invading pathogens that are linked by mutual ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

In addition, EphA2-mediated NLRP3 phosphorylation is crucial for amelioration of pathological asthmatic exacerbation in a mouse model of asthma.

Inflammaging: disturbed interplay between autophagy ... - Aging-US

However, during aging, the autophagic capacity declines and increased ROS production and aggregated proteins activate inflammasomes which provoke a low-grade ...

Regulation of the Inflammasomes by Autophagy - ResearchGate

... Autophagy is a self-protective process in the body. Previous studies have shown that autophagy can negatively or positively regulate NLRP3 inflammasome ...

Crosstalks between inflammasome and autophagy in cancer

Both inflammasomes and autophagy have important roles in the intracellular homeostasis, inflammation, and pathology; the dysregulation of ...

Inflammasome and Autophagy Regulation: A Two-way Street

Autophagy has now been identified as a main regulator of inflammasomes, allowing for a two-way mutual regulation of inflammation that may hold the key for ...