- Regulation of tissue iron homeostasis🔍
- Current understanding of iron homeostasis🔍
- Tissue|Specific Regulation of Iron Metabolism and Heme Synthesis🔍
- Regulation of Iron Homeostasis and Related Diseases🔍
- Iron Homeostasis🔍
- Regulators of Iron Homeostasis🔍
- Iron metabolism and iron disorders revisited in the hepcidin era🔍
- Key players in the regulation of iron homeostasis at the host ...🔍
Regulation of tissue iron homeostasis
Regulation of tissue iron homeostasis: the macrophage “ferrostat”
Tissue-resident macrophages regulate local iron availability and modulate the tissue microenvironment, contributing to cellular and tissue function.
Regulation of tissue iron homeostasis: the macrophage "ferrostat"
Iron is an essential element for multiple fundamental biological processes required for life; yet iron overload can be cytotoxic.
Regulation of tissue iron homeostasis: the macrophage “ferrostat”
Mɸs sequester extracellular iron to decrease iron uptake in the injured parenchymal cell. LIP has been reported to increase in response to cell injury.
Current understanding of iron homeostasis - ScienceDirect.com
However, most cells are able to export iron through FPN1 and, thus, are potential hepcidin targets. Hepcidin regulation has been studied extensively but ...
Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis
Heme biosynthesis involves 8 enzymes, 4 of which are cytoplasmic and 4 which are localized in the mitochondria.
Regulation of Iron Homeostasis and Related Diseases - Li - 2020
The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway ...
Iron Homeostasis - an overview | ScienceDirect Topics
Iron homeostasis is maintained at stable concentrations in the plasma and tissues by tight regulation of dietary absorption and conservation of stores.
Regulators of Iron Homeostasis: New Players in Metabolism, Cell ...
Iron is necessary for life, but can also cause cell death. Accordingly, cells evolved a robust, tightly regulated suite of genes for maintaining iron ...
Iron metabolism and iron disorders revisited in the hepcidin era
In iron deficiency, cells may recover iron through ferritinophagy, a process mediated by the multifunctional protein NCOA4.2625 First described ...
Key players in the regulation of iron homeostasis at the host ...
Tsf binds approximately all iron released to the plasma from the diet to prevent the formation of free radicals and ensure its transport to target cells (29).
Liver iron sensing and body iron homeostasis - ASH Publications
Both tissue iron and plasma iron levels are sensed by the liver to regulate hepcidin production. Iron loading increases transferrin-bound iron ( ...
New regulators of systemic iron homeostasis - Nature
In this relatively constant interior environment, the distribution of iron to individual cells is governed by cell-autonomous iron uptake ...
Systemic Iron Homeostasis | Physiological Reviews
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: ...
Differential regulation of iron homeostasis during human ...
Macrophages play a critical role in body iron homeostasis by recovering iron from old red blood cells and returning it to the circulation for ...
Cellular Iron Metabolism and Regulation - SpringerLink
Iron metabolism at the cellular level and the whole systemic level are tightly regulated. Balance of iron homeostasis depends on the expression levels and ...
Two to Tango: Regulation of Mammalian Iron Metabolism - Cell Press
Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ...
Regulation of iron homeostasis by the hypoxia-inducible ...
We hypothesized that this pathway could play a role in hepcidin regulation because: (a) iron deprivation and hypoferric anemia lead to poor tissue oxy- genation ...
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis
Such iron disorders may be caused by genetic lesions that directly impair iron regulation, or conditions that impact iron regulation indirectly.
Human iron metabolism - Wikipedia
Hematologists have been especially interested in systemic iron metabolism, because iron is essential for red blood cells, where most of the human body's iron is ...
Gateways of cellular and systemic iron homeostasis
Hepcidin, the iron-regulatory protein produced by hepatocytes, controls the flow of iron into the plasma by binding to ferroportin (on enterocytes, macrophages, ...