Remodeling of T|cell mitochondrial metabolism to treat autoimmune ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune ...

T cells are key drivers of the pathogenesis of autoimmune diseases by producing cytokines, stimulating the generation of autoantibodies, and mediating ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune ...

Article on Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases, published in Autoimmunity Reviews 23 on 2024-06-01 by ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune ...

Request PDF | On Jul 1, 2024, Liyan Lin and others published Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases ...

Age-associated remodeling of T cell immunity and metabolism - PMC

Age-associated mitochondrial and metabolic reprogramming has a direct impact on the immune system and its role in diseases such as cancer, autoimmunity and ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune ...

Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases ... Authors: Liyan Lin; Ruyu Ren; Qiao Xiong; Chunfu Zheng; Bin Yang; Huiqing Wang.

Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases - MDPI

Thus, remodeling glucose metabolism in T-cells by regulating LDHA activity is an attractive approach to potentially reduce chronic inflammation and autoimmunity ...

Mitochondrial Oxidative Damage Underlies Regulatory T Cell ...

These findings highlight an unrecognized role of mitochondrial oxidative stress in defining Treg fate during autoimmunity, which may facilitate ...

Mini-review Mitochondrial activity in T cells - ScienceDirect.com

Mitochondrial metabolism decides T cell differentiation and fate. Increasing aerobic glycolysis and glutaminolysis leads to a proinflammatory effector phenotype ...

Itaconate ameliorates autoimmunity by modulating T cell imbalance ...

To investigate the potential of ITA as a candidate to treat autoimmune diseases, we used an experimental autoimmune encephalomyelitis (EAE) ...

Mitochondrial Control for Healthy and Autoimmune T Cells - MDPI

In recent decades, accumulating studies have pinpointed immunometabolism as the fundamental determinant in controlling T cell fate. Specifically, mitochondria, ...

Rewiring Mitochondrial Metabolism for CD8+ T Cell ... - Frontiers

in regulating CD8+ T cell fate decision and antitumor immunity. Importantly, targeting mitochondrial metabolism to boost T cell memory formation and metabolic ...

CD4+ T cell metabolism, gut microbiota, and autoimmune diseases

Treatment of dichloroacetate, which shifts glucose metabolism from glycolysis to pyruvate oxidation, leads to increased IL-10 production in Th17 cells,93 ...

Rewiring mitochondrial metabolism to counteract exhaustion of CAR ...

Treatment with mitochondria-targeted (MT) antioxidants may be a new strategy to prevent cytotoxic T cell exhaustion. Antioxidant treatment ...

Age-associated remodeling of T cell immunity and metabolism

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes in age-related diseases such as cancer.

Metabolic Plasticity of Regulatory T Cells in Health and Autoimmunity

A recent report has also highlighted the key role of mitochondrial metabolism in the control of Treg cell fate in MS. Indeed, Alissafi et al. ( ...

Mitochondrial dysfunctions in T cells: focus on inflammatory bowel ...

Accordingly, the treatment of the ROS scavenger, N-acetyl-L-cysteine (NAC), or the mitochondria-targeted anti-oxidant, mitoquinone (MitoQ), in T cells ...

Teriflunomide treatment for multiple sclerosis modulates T cell ...

Interference with immune cell proliferation represents a successful treatment strategy in T cell–mediated autoimmune diseases such as rheumatoid ...

Cellular metabolism regulates the differentiation and function of T ...

... autoimmune disorders. In both ... Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation.

Regulatory T cell metabolism at the intersection between ...

Regulatory T cells exert immune tolerance and are critical for immune homeostasis. Tregs, which are implicated in autoimmunity and cancer, ...

Metabolism along the life journey of T cells - Oxford Academic

The roles of common metabolic pathways, including glycolysis, lipid metabolism, and mitochondrial oxidative phosphorylation, in T-cell responses have been well ...