Reporting of Subgroup Analyses in Clinical Trials

Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...

By “subgroup analysis,” we mean any evaluation of treatment effects for a specific end point in subgroups of patients defined by baseline characteristics. The ...

Statistics in medicine--reporting of subgroup analyses in clinical trials

Statistics in medicine--reporting of subgroup analyses in clinical trials.

Reporting of subgroup analyses from clinical trials - The Lancet

Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems

Reporting of Subgroup Analyses in Clinical Trials

Abstract. The analysis of subgroups is often used as a way to glean additional information from data sets. The strengths and weaknesses of this approach and new ...

How to understand subgroup analysis in clinical studies

The challenge of subgroup analyses--reporting without distorting. N Engl J Med. 2006 Apr 20;354(16):1667-9. Page 12 ...

What a Clinician Ought to Know: Subgroup Analyses

WHAT ARE SUBGROUP ANALYSES? In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint ( ...

Statistical Considerations for Subgroup Analyses - PMC

Unlike confirmatory subgroup analysis, exploratory subgroup analyses are intended to obtain preliminary evidence and to generate hypotheses for future ...

Statistics in medicine–reporting of subgroup analyses in clinical trials

Statistics in medicine–reporting of subgroup analyses in clinical trials. Reporting guidelines for main study types.

Subgroup Analyses in Reporting of Phase III Clinical Trials in Solid ...

We investigated the appropriateness of the use and interpretation of subgroup analyses in oncology RCTs on the basis of the CONSORT statement requirements.

Subgroup analyses in confirmatory clinical trials: time to be specific ...

Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clinical trials, where conclusions ...

Same Old Challenges in Subgroup Analysis—Should We Do More ...

Sherry et al considered the methodological quality of subgroup analyses reported in 379 oncology trials. The authors explored a number of ...

When to believe a subgroup analysis: revisiting the 11 criteria - Nature

A systematic review of subgroup analyses ... Quality of reporting of key methodological items of randomized controlled trials in clinical ...

Justification and reporting of subgroup analyses were lacking or ...

Subgroup analysis in clinical trials aims to detect subgroup effects, defined as the difference in treatment effect between subgroups because of causal ...

Reporting of subgroup analyses from clinical trials - The Lancet

reported the subgroup analyses of the FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis (FREEDOMS) study,.

Evaluation of Planned Subgroup Analysis in Protocols of ...

This cross-sectional study compares randomized clinical trial protocols to assess the prevalence and reporting quality of planned subgroup ...

Characteristics of post hoc subgroup analyses of oncology clinical ...

JM. Statistics in medicine—reporting of subgroup analyses in clinical trials . N Engl J Med . 2007. ;. 357. (. 21. ): 2189. -. 2194 . doi:.

Understanding of interaction (subgroup) analysis in clinical trials

This article provides a brief non-statistical guide for clinical investigators on how to perform, interpret and report interaction (subgroup) analyses in RCTs.

The influence of study characteristics on reporting of subgroup ...

Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine reporting of subgroup analyses in clinical trials. N Engl J Med 2007; ...

A systematic review of subgroup analyses in randomised clinical ...

Relying on reported data, we examined the relation between the frequency of reported subgroup analyses and various trial characteristics, such ...

Cumulative subgroup analysis to reduce waste in clinical research ...

In case study 1, an IPD meta-analysis of 10 randomised trials (RCTs) on beta blockers for heart failure reported significant interaction of ...