Reprogramming and plasticity of epigenetic regulation

Reprogramming and plasticity of epigenetic regulation - YouTube

Prof Petra Hajkova MRC London Institute of Medical Sciences (LMS), London https://lms.mrc.ac.uk/research-group/reprogramming-and-chromatin/ ...

Metabolic reprogramming and epigenetic modifications in cancer

In cancer cells, metabolic pathway activity varies during tumorigenesis and cancer progression, indicating regulated metabolic plasticity.

Epigenetic Regulation of Epithelial to Mesenchymal Transition in the ...

Mechanistically, these EMT-TFs are regulated at a transcriptional level by DNA methylation, histone modifications, and RNA-mediated epigenetic regulation (6, 22) ...

Regulation of Reprogramming and Cellular Plasticity ... - PubMed

During this transition, drastic changes in transcriptional programs occur in parallel with global chromatin reorganization. The epigenetic mechanisms governing ...

Child Health, Developmental Plasticity, and Epigenetic Programming

Epigenetic mechanisms of gene regulation are relevant throughout development from when the sperm first meets the egg, through early lineage decisions, to fetal ...

Epigenetic Reprogramming During Development - BioMed Central

Epigenetic reprogramming during development coordinates crucial changes in gene expression patterns without altering DNA sequences.

Role of Epigenetic Regulation in Plasticity of Tumor Immune ...

Epigenetic alterations, such as DNA methylation, histone post-translational modifications, and noncoding RNA-mediated regulation, regulate the expression of ...

Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming ...

Epithelial-to-Mesenchymal Transition Controlling Cellular Plasticity in Development and Disease · Molecular Regulation of EMT · EMT and Epigenetic Regulation.

Epigenetic regulation of aging: implications for interventions ... - Nature

Small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or ...

Epigenetic regulation of cell fate reprogramming in aging and disease

Whereas resilient states maintain large epigenetic barriers refractory to reprogramming cellular identity, plastic states lower these barriers, and increase the ...

Epigenetics as a mediator of plasticity in cancer - Science

In particular, epigenetic regulation may have a critical role in regulating variability of gene expression, accounting for variance in current ...

Decoding the Epigenetic Language of Neuronal Plasticity - Cell Press

Epigenetic control, which largely involves events of chromatin remodeling, appears to be one way in which transcriptional regulation of gene expression can be ...

Reprogramming of cell fate: epigenetic memory and the erasure of ...

Multiple chromatin remodelling factors have been shown to regulate both ES cell identity and somatic cell reprogramming by their chromatin shaping activities.

Editorial: Epigenetic Regulation of Stem Cell Plasticity in Tissue ...

Such a powerful approach however does not come without risks. The reprogramming process per se and the remarkable transcriptional and epigenetic ...

Sarah S. Richardson Plasticity and Programming - jstor

Epigenetics refers to molecular mechanisms that regulate DNA expression in response to genetic and nongenetic cues. Studies of epigenetic mechanisms arrived ...

Epigenetics and metabolism at the crossroads of stress-induced ...

Phenotypic plasticity provides cancer cells an initial survival advantage that allows them to accumulate genetic changes or imprint epigenetic memory, leading ...

Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay ...

Moreover, we propose a review of the main epigenetic mechanisms whose deregulation can favor the onset of CSC features both in tumor initiation ...

Epigenetic regulation of early human embryo development

Recent studies have now produced the first epigenetic maps of early human embryogenesis, stimulating new ideas about epigenetic reprogramming, cell fate ...

The epigenetic regulation of adipose tissue plasticity - PNAS

(4) provides compelling evidence that DNA methylation by DNA methyltransferase 1 (DNMT1) serves as a critical epigenetic regulator of adipose tissue plasticity ...

Temporal and epigenetic regulation of neurodevelopmental plasticity

We propose that understanding the processes of epigenetic programming within the neural lineage is likely to lead to the development of more rationale ...