Reprogramming of host energy metabolism mediated by the TNF ...

Our findings reveal that TNF-iNOS-HIF-1α-induced glycolysis in monocytes plays a critical role in host defense and sickness behavior in Pc-infected mice.

Figures and data · 1. P. chabaudi-infected mice display enhanced TNF production associated with increased disease parameters. · 2. The ...

Reprogramming of host energy metabolism mediated by the TNF ...

PDF | TNF has a dual effect in Plasmodium infection, bolstering the host's immune defense while also triggering disease. Here, we show that TNF.

Reprogramming of host energy metabolism mediated by the TNF ...

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection ... Authors: Kely C ...

Reprogramming of host energy metabolism mediated by the TNF ...

TNF has a dual effect in Plasmodium infection, bolstering the host's immune defense while also triggering disease. Here, we show that TNF signaling hampers ...

Reprogramming of host energy metabolism mediated by the TNF ...

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection · Curated by eLife · This ...

Reprogramming of host energy metabolism mediated by the TNF ...

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1alpha axis plays a key role in host resistance to Plasmodium infection. bioRxiv, p. 1 ...

Reprogramming of host energy metabolism mediated by the TNF ...

Request PDF | Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection | TNF ...

Reprogramming of host energy metabolism mediated by the TNF ...

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance toPlasmodiuminfection.

Reprogramming of host energy metabolism mediated by the TNF ...

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1alpha axis plays a key role in host resistance to Plasmodium infection.

TNFα-induced metabolic reprogramming drives an intrinsic anti-viral ...

Further, we show that glycolysis is broadly important for TNFα-mediated anti-viral defense, as its inhibition attenuates TNFα's ability to limit the replication ...

Macrophage derived TNFα promotes hepatic reprogramming to ...

Overall, we suggest that macrophages, as early sensors of pathogens, instruct hepatocytes via TNFα to undergo metabolic reprogramming to cope with challenges to ...

Reprogramming of host energy metabolism mediated by the TNF ...

Metabolic Reprogramming Mediated by TNF-iNOS-HIF-1α Axis Regulates Host Resistance and Tolerance to Plasmodium Infection · Core Concepts · Abstract.

TNF-α signals through ITK-Akt-mTOR to drive CD4+ T cell metabolic ...

The effects of TNF-α were mediated by activation of Akt-mTOR signaling by the kinase ITK and did not require the NF-κB pathway. TNF-α stimulated ...

Metabolic reprogramming of host cells by virulent Francisella ...

A shift in macrophage metabolism from oxidative phosphorylation to aerobic glycolysis is a requirement for activation to effectively combat invading ...

Metabolic Messengers: tumour necrosis factor - Nature

Similarly, signals mediated by TNF–RSC I are crucial mediators of metabolic reprogramming, in part through crosstalk with other intracellular ...

Cancer energy reprogramming and the immune responses

Cancer metabolism entails signaling and regulation of anti-tumor immune response to sustain the progress of tumorigenesis. Through the releasing of metabolites, ...

Metabolic Reprogramming in Immune Response and Tissue ...

Mitochondria play a key regulatory role during an immune response to coordinate the production of energy and mitochondrial ROS, fatty acid ...

Lipid metabolic reprogramming in tumor microenvironment

Consequently, tumor cells must alter their metabolic patterns to enhance the utilization of lipids for energy supply to sustain their biological ...

Species-specific metabolic reprogramming in human and mouse ...

Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from ...