Research progress on chromothripsis and tumorigenesis

Chromothripsis is a complex genomic rearrangement event in which localized regions of one or several chromosomes fragment in response to stress.

Chromothripsis in cancer | Nature Reviews Cancer

This extreme form of genome instability has been detected in 30–50% of cancers. Studies conducted in the past few years have uncovered insights ...

Some criteria have been proposed to infer whether chromothripsis occurs in the genome. Recent clinical cohort studies have shown that the clinical prognosis of ...

Pan-cancer analysis of chromothripsis-related gene expression ...

In a single chromothripsis incident, hundreds of DNA breaks can occur in a short time. Consequently, overwhelmed or erroneous DNA repair ...

Genetic hallmarks and clinical implications of chromothripsis in ...

It can cause cancer-promoting alterations, such as loss of sequences for tumor-suppressor genes, formation of oncogenic fusions, and oncogene ...

Chromothripsis drives the evolution of gene amplification in cancer

Previous studies showed that ecDNA elements can integrate into chromosomes. We initially tested the role of DNA damage in this process by inducing random double ...

Chromothripsis-mediated small cell lung carcinoma - AACR Journals

We found that most cases were associated with chromothripsis – massive, localized chromosome shattering – recurrently involving chromosomes 11 ...

Chromothripsis and genomic instability from mitotic errors

Although the precise role of aneuploidy in tumorigenesis remains under debate due to a proliferative disadvantage bestowed upon non-transformed ...

Chromothripsis and Circular Recombination Drive Oncogene ...

Further analysis found that chromothripsis, a catastrophic mutational event that leads to chromosome rearrangement of a genomic region, was ...

On the Complexity of Mechanisms and Consequences of ... - Frontiers

In the present review, we focus on the phenomenon of chromothripsis, a new type of complex chromosomal rearrangements.

Chromothripsis is rare in IDH-mutant gliomas compared to IDH-wild ...

GBM displays genome instability, which may result from 2 genetic events leading to massive chromosome alterations: Chromothripsis (CT) and whole ...

Chromothripsis: A New Frontier in Cancer Research

Chromosomal abnormalities like chromothripsis are at the heart of many cancers, and properly understanding them requires next-generation ...

Chromosomal Rearrangements and Chromothripsis: The Alternative ...

Other studies showed that exogenous sources of DNA damage, i.e., viral infections, could induce genomic rearrangements [38,62]. Using human ...

Chromothripsis is correlated with reduced cytotoxic immune ...

In this study, we investigated the association among chromothripsis, anti-tumor immune responses, and responsiveness to immune checkpoint ...

Chromothripsis - an overview | ScienceDirect Topics

Chromothripsis may drive cancer development through a variety of oncogenic lesions such as formation of fusion genes, disruption of tumor suppressors or ...

Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force ...

Due to the associated chromosomal rearrangements, it has a significant impact on the pathophysiology of the disease. Recent studies have suggested that ...

Chromothripsis-like patterns are recurring but heterogeneously ...

Chromothripsis is a recently discovered phenomenon of genomic rearrangement, possibly arising during a single genome-shattering event.

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

In contrast to the traditional view of tumorigenesis as a gradual Darwinian process of progressive mutation accumulation, chromothripsis ...

A cell‐based model system links chromothripsis with hyperploidy

During tumorigenesis, a single genetic alteration (or “hit”) is generally thought to be insufficient for a cell to develop into cancer. Instead, several ...

... studies have proposed models to explain the initiation of chromothripsis, few discussed how TFs influence this process for tumor progression ...