Research progress on the activation mechanism of NLRP3 ...

NLRP3 inflammasome promotes inflammatory response by controlling the activation of caspase-1 and the release of pro-inflammatory cytokines interleukin IL-1β ...

Research progress on the activation mechanism of NLRP3 ... - NCBI

It was found that NLPR3 inflammasomes are closely related to sepsis and septic cardiomyopathy (SCM) and can be involved in regulating SCM ...

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013; 38(6): 1142-1153.

(PDF) Research progress on the activation mechanism of NLRP3 ...

The role of NLRP3 inflammasome has received increasing attention, but its activation mechanism and regulation of inflammation in SCM remain to be investigated.

Research progress of NLRP3 inflammasome and its inhibitors with ...

Both the upstream signaling molecules MyD88 and TRIF of the NF-kB signaling pathway are able to modulate the induced activation of NLRP3 and ...

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Aberrant NLRP3 activation has been shown to exacerbate disease pathology in several inflammation-driven diseases, and ongoing research is investigating the ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

During cellular stress responses, stress granules are critical to cell survival. A recent study showed that the stress granule protein DEAD-box ...

Mechanisms of NLRP3 inflammasome activation and the ...

Upon activation, NLRP3 inflammasome initiates the release of inflammatory cytokines and triggers a form of cell death known as pyroptosis. Dysregulation or ...

Research Progress of Mitochondrial Mechanism in NLRP3 ... - MDPI

NLRP3 is an important pattern recognition receptor in the innate immune system, and its activation induces a large number of pro-inflammatory cytokines, ...

[PDF] Research Progress of Mitochondrial Mechanism in NLRP3 ...

The mechanism of NLRP3 inflammasome activation is discussed mainly from the perspective of mitochondria in this review, and the effect and potential ...

The mechanism of NLRP3 inflammasome activation and its ...

Thus, NLRP3 is an important therapeutic target, and researchers are putting a lot of effort into developing its inhibitors. The review summarizes the latest ...

Research progress on related mechanisms of uric acid activating ...

The NLRP3 inflammasome is activated in various autoinflammatory and autoimmune diseases (such as gout, rheumatoid arthritis and systemic lupus erythematosus) [ ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Upon activation, the inflammasome also promotes an inflammatory form of cell death named pyroptosis, which is regulated by the N-terminal domain ...

(PDF) Research Progress of Mitochondrial Mechanism in NLRP3 ...

In recent years, it has been suggested that mitochondria are the platform for NLRP3 inflammasome activation. Additionally, exercise is ...

Research progress on NLRP3 inflammasomes in male reproductive ...

Activation of the typical inflammasome pathway of NLRP3/caspase-1 and IL-1β induces the secretion of inflammatory cytokine secretion and immune ...

NLRP3 Inflammasomes: Dual Function in Infectious Diseases

typhimurium TAcnB was also found to inhibit NLPR3 inflammasome activation through the same mechanism (50). A recent study has shown that ...

Mechanism and Regulation of NLRP3 Inflammasome Activation

Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 inflammasome in immunity and ...

A narrative review of research progress on the role of NLRP3 ...

There are two signals for the activation of the NLRP3 inflammasome. The first signal is the activation of the nuclear factor kappa-light-chain- ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ... - MDPI

The role of mitochondrial ROS (mtROS) in NLRP3 inflammasome activation was originally proposed from a study showing that mtROS, as generated by the inhibition ...

Mechanism of NLRP3 inflammasome activation and its role in ...

Study has found that linarin (LR) inhibited LPS-induced oxidative stress and the release of proinflammatory cytokines by inhibiting proteins and ...