Researchers Target a Major Hurdle for Retinal Stem Cell Replacement

Read how Mount Sinai researchers are tackling a major hurdle to using stem cells to treat age-related macular degeneration.

... major adverse event in the use of induced pluripotent stem cells ... Researchers Target a Major Hurdle for Retinal Stem Cell Replacement.

Retina stem cells, hopes and obstacles - PMC - PubMed Central

The finding of stem cells (SC) in the eye has led to the proposal of cell replacement strategies for retina degeneration. Therapies using different types of SC, ...

The Future of Stem Cell Therapy in Retina

2 Although the eye is structurally complex, the number of different cell types it contains is low, and so retinal stem cell therapies can be targeted to replace ...

Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa - PMC

Gene therapy has been shown to improve visual function in inherited retinal disease [11,12]. RP is a hereditary cause of blindness, which has four main modes of ...

Stem Cell Advances: Successes and Challenges

On the retina front, said Dr. Singh, “Any condition in which the retinal cells are degenerating is a potential candidate for stem cell therapy ...

Retinal stem cell transplantation: Balancing safety and potential

The eye, and specifically the retina, is an excellent target for cellular replacement therapies for several reasons. First, the transplantation site and cells ...

Stem cell transplants show promise for macular hole repair in monkeys

Human stem cell transplants successfully repaired macular holes in a monkey model, researchers report October 3 rd in the journal Stem Cell Reports.

Stem cell sources and characterization in the development of cell ...

Stem cell-based replacement therapy in retinal degenerative diseases. Current research indicates that we may soon be able to replace lost or ...

A treatment within sight: challenges in the development of stem cell ...

Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal ...

Exploring Stem-Cell-Based Therapies for Retinal Regeneration - MDPI

Clinical trials of stem cell therapy in degenerative macular diseases represent a cutting-edge frontier in ophthalmological research, focusing on retinal ...

Stem Cells for Retinal Replacement Therapy - ScienceDirect.com

Active research aims to determine which stem cells are best suited to replace the retina and to identify the retinal layers and diseases most amenable to stem ...

Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy ...

(Another phase I/II trial involving scaffold-based autologous iPSC-RPE is in progress [Autologous Transplantation of Induced Pluripotent Stem ...

Stem cell therapy clears first hurdle in AMD | Nature Biotechnology

In two studies, 18 patients, with either atrophic, dry, age-related macular degeneration (AMD) or Stargadt's macular dystrophy, a genetic ...

Restoring Vision with Stem Cells - Fighting Blindness Canada (FBC)

Research is focusing on two main cell types for replacement: photoreceptors and retinal pigment epithelium (RPE). There are other cell types ...

Outer Retinal Cell Replacement: Putting the Pieces Together - TVST

Human pluripotent stem cell (hPSC) technologies have accelerated development of outer retinal cell therapies as they provide a theoretically unlimited source of ...

Stem cell-derived retinal pigment epithelium cell therapy - Frontiers

... research involving stem-cell derived RPE cell transplantation for retinal disease ... target for novel cell-based treatment approaches ...

Scientists take important step toward using retinal cell transplants to ...

To restore this population of cells, the researchers extracted retinal stem cells from donated cadaver adult eyes, which can enable donor ...

Human-induced pluripotent stem cells-derived retinal pigmented ...

The goal of RPE cell therapy is to return the normal structure and function of the retina by re-establishing its interaction with photoreceptors ...

Preface: Sight Restoration Through Stem Cell Therapy - IOVS

Moreover, progress is being made in several other research areas, such as stem cell therapy, that allows for current clinical trials on sight restoration or ...