Researchers find metabolic mechanism that blocks immune ...

New research has discovered why some cancers don't respond to immunotherapy treatment: A metabolite transporter within the tumor ...

Metabolic mechanism provides a new target for improving cancer ...

Going a step further, researchers uncovered the mechanism driving this: tumor cells use SLC13A3 to uptake a metabolite called itaconate. Then, ...

CHOP Researchers Discover Key Metabolic Process Responsible ...

A metabolite called NAD encourages immune cells to divide more quickly and could be used to improve efficacy of cell-based therapies.

Scientists Identify Protein That's Crucial to Tumor Cells' Metabolism ...

BOSTON – Tumor cells typically alter their energy metabolism and increase glucose uptake to support their rapid division and spread. This limits ...

Metabolic regulation of the immune system in health and diseases

The interactions between metabolism and immunity have attracted many researchers. The relationship between metabolism and immunity have been ...

Researchers Find Altering Metabolism in Immune Cells Helps ...

Johns Hopkins Medicine researchers have determined that macrophages — white blood cells that surround and kill microorganisms, remove dead ...

A Cascade of Immune Processes Offers Insights to Triple-Negative ...

Researchers have discovered the process that allows immune suppressor cells to develop, suggesting a potential new way to bolster ...

Researchers map metabolic signaling machinery for producing ...

Discovery of a metabolic pathways that inhibit memory T cell production has potential for enhancing the immune system's ability to fight infections and cancers.

Scientists identify immune molecule that keeps metabolism in tune ...

In a recent study led by Professor Lydia Lynch and published in leading international journal Nature, researchers report that key immune cells – ...

Targeting Metabolism in APS and Lupus - Research

Researchers find metabolic mechanism that blocks immune response, immunotherapy in cancer. 11/7/2024. New research has discovered why some ...

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Researchers Find Metabolic Mechanism That Blocks Immune Response, Immunotherapy in Cancer. Researchers at the University of Michigan Rogel Cancer Center have ...

“Oncometabolite” Neutralizes Immune Cells Near IDH-Mutant Tumors

The answer, they reported, is that D-2HG appears to blocks an enzyme called LDH, which plays a pivotal part in T cell metabolism. That ...

Unveiling the growing significance of metabolism in modulating ...

The orchestration of metabolic pathways plays a pivotal role in activating immune cells, furnishing the essential energy and molecular building blocks necessary ...

Targeting 'broken' metabolism in immune cells reduces inflammatory ...

Scientists have found a way to 'program' immune cells to cause less damage to the body, by tapping into a 'broken' chemical pathway in inflammation.

Targeting 'broken' metabolism in immune cells reduces inflammation

Scientists have uncovered a way to 'program' immune cells to cause less damage to the body, by tapping into a 'broken' chemical pathway in ...

Metabolic Regulation of Immune Responses - PMC

First, it provides the substrates for ATP synthesis to sustain the various cellular programs of activated immune cells. Second, it provides the building blocks ...

Targeting Metabolism in APS and Lupus | University of ... - Research

Research · logo ... Home. Research News. Targeting Metabolism in ... Researchers find metabolic mechanism that blocks immune response, immunotherapy in cancer.

Immunometabolism at the intersection of metabolic signaling, cell ...

The integration of metabolism with immunity, known as immunometabolism, is at the forefront of immunology research, as it continues to transform the field.

Cells can use uridine, a component of RNA, as a source of energy

Researchers have discovered a new biochemical pathway in cells that could contribute to the immune response as well as some cancers and metabolic disorders.

After Years of Neglect, Cancer Biologists Return to a Forgotten Field

“This was a transformative idea,” says Ming Li, an immunologist at the Sloan Kettering Institute who studies metabolism in immune cells. “The ...