Researchers find response to ketamine depends on opioid ...

In a study of rats, the researchers found that blocking opioid receptors in the brain extinguished the effects of ketamine — but only in male ...

Sex dependence of opioid-mediated responses to subanesthetic ...

Recent clinical evidence has indicated, controversially, that a component of the efficacy of subanesthetic ketamine may be opioid dependent.

Anesthesiology & Pain Management | News Center

Researchers find response to ketamine depends on opioid pathways, but varies by sex ... A new study in rats led by Stanford Medicine researchers looked at whether ...

Researchers find response to ketamine depends on opioid ...

02/12/2024. Researchers find response to ketamine depends on opioid pathways, but varies by sex. A new study in rats led by Stanford Medicine researchers ...

Opioid Receptor Antagonism Attenuates Antidepressant Effects of ...

In addition to N-methyl D-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of the study was to determine ...

Drug that acts like ketamine—but without the potential for abuse or ...

Researchers say a drug developed for improving thinking has the ability to act like the drug ketamine, which is being studied for its antidepressant effects.

Ketamine – More mechanisms of action than just NMDA blockade

In vitro Gupta and colleagues found that ketamine prevented and even reversed opioid mu-receptor desensitisation, acting downstream of the receptor on the ...

Ketamine for pain management - PAIN Reports

The review found that ketamine reduced opioid requirements, and may improve pain control, at the same time noting the significant limitations of the current ...

The endogenous opioid system in the medial prefrontal cortex ...

Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate glutamate receptors (NMDARs), has been found to have rapid antidepressant and anti ...

Researchers Discover That Fast-Acting Antidepressant Ketamine ...

Ketamine has been used for decades as an anesthetic and occasionally as a pain reliever. In recent years the drug has been used experimentally ...

Ketamine Isn't an Opioid and Treats Depression in a Unique Way

In late 2018, researchers at Stanford University and Palo Alto University showed that naltrexone also blocks the antidepressant effects of ...

Ketamine as an antidepressant: overview of its mechanisms of ...

It has been proposed that ketamine's anti-suicidal and antidepressant effects may depend on activation of the opioid system, since pre-treatment with naltrexone ...

What ketamine can teach us about the opioid system in depression?

As far as we know, ketamine has a very low affinity at µ-opioid (MOR) and κ-opioid receptors. Thus, it is unlikely that ketamine's ...

Historical Pathways for Opioid Addiction, Withdrawal with Traditional ...

Of particular interest to the subject at hand, ketamine is promising in treating individuals addicted to opioids, alcohol, and cocaine.

Stanford Medicine - X

Research by Stanford Medicine scientists suggests that ketamine's ... Researchers find response to ketamine depends on opioid pathways, but varies ...

Ketamine, A Promising Depression Treatment, Seems To Act ... - NPR

A Stanford research team finds that ketamine's ability to quickly relieve depression may depend on activating the brain's opioid system.

RESEARCHERS FIND RESPONSE TO KETAMINE DEPENDS ON ...

A new study in rats led by Stanford Medicine researchers looked at whether ketamine's effects depend on opioid pathways -- and uncovered a surprising difference ...

A Review of Nonanesthetic Uses of Ketamine - Pribish - 2020

A study of 58 opioid-dependent patients found that subanesthetic ketamine infusion (0.5 mg/kg/hour) significantly improves immediate and ...

Ketamine and hydroxynorketamine as novel pharmacotherapies for ...

Evidence supports the notion that ketamine, an anesthetic and rapid-acting antidepressant drug, holds promise as a candidate for OUD treatment, including the ...

NMDA Receptor Activation-Dependent Antidepressant-Relevant ...

We found that ketamine exerts an inverted U-shaped dose-response in antidepressant-sensitive behavioral tests, suggesting that an excessive NMDAR inhibition ...