Reshaping of the tumor microenvironment by cellular senescence

Senescent cells lingering in the tumor microenvironment (TME) can contribute to tumor progression, metastasis, and therapy resistance.

Reprogramming cellular senescence in the tumor microenvironment ...

Harnessing the immunogenic potential of senescent tumor cells provides an opportunity to remodel tumor microenvironment (TME) and boost ...

Targeting senescent cells to reshape the tumor microenvironment ...

Senescent cells arising in the tumor microenvironment (TME) contribute to tumor progression, including augmented therapeutic resistance.

Cellular senescence and SASP in tumor progression and ...

These factors significantly reshape the tumor microenvironment (TME), enabling tumors to evade immune destruction. Interestingly, some studies ...

Cellular senescence and the tumour microenvironment - FEBS Press

In this review, we discuss the features and roles of senescent cells in tumour microenvironment with emphasis on their context-dependency.

Reshaping of the tumor microenvironment by cellular senescence

Cellular senescence is a stress response associated with aging and disease, including cancer. Senescent cells undergo a stable cell cycle arrest, ...

Cellular senescence in the tumor microenvironment and context ...

Moreover, senescent cells in the tumor microenvironment (TME) showing the SASP help to promote tumor proliferation and metastasis in various ...

Targeting senescent cells to reshape the tumor microenvironment ...

Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy · Birong Jiang ·, Wei Zhang ·, Xuguang Zhang · and Yu Sun.

Senescent Stromal Cells in the Tumor Microenvironment - MDPI

The dark side of cellular senescence promotes tumor progression, distant metastasis, immune infiltration, and resistance against antitumor therapy [18]. These ...

Reshaping of the tumor microenvironment by cellular senescence

Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies · List of references · Publications that cite this publication.

Exploiting senescence for the treatment of cancer - Nature

We describe the distinctive features of senescent cancer cells and how these changes in cellular physiology might be exploited for the selective ...

Reshaping of the tumor microenvironment by cellular senescence

Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies · journal article · review article · Published by Elsevier in ...

Targeting senescent cells to reshape the tumor microenvironment ...

Tao, Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators, Cell Metab. https://doi.org/10.1016/j.cmet.2024.03.009 ...

Pancreatic Cancer and Cellular Senescence: Tumor ... - MDPI

Understanding the interactions between tumors and their microenvironment is a growing research field, with evidence having been provided that non-tumoral cells ...

Tumor microenvironment and cellular senescence - Europe PMC

Importantly, therapy-induced senescence (TIS) of cells in the TME is frequently observed in anticancer regimens, an off-target effect that can ...

RAS Dialogue | Senescent Macrophages and KRAS - NCI

Non-cell autonomy in cancer development extends beyond the intrinsic genetic alterations in cancer cells. Oncogenes like RAS have effects that ...

Senescence and cancer — role and therapeutic opportunities - Nature

Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory, ...

Senescence and Immunoregulation in the Tumor Microenvironment

Non-cancerous cells that make up tumors are collectively referred to as the TME, and include immune cell subsets (Binnewies et al., 2018), ...

Comprehensive assessment of cellular senescence in the tumor ...

Cellular senescence (CS), defined as the irreversible arrest of the cell cycle, is a critical component of the four layers of aging and cancer ...

Senescent cells and SASP in cancer microenvironment - Europe PMC

The treatment with chemotherapeutics induces cellular senescence in normal and cancer cells in the tumor microenvironment. Thus therapy-induced senescence in ...