Resistance to Checkpoint Inhibition in Cancer Immunotherapy

Resistance to Checkpoint Inhibition in Cancer Immunotherapy - PMC

Our review seeks to bridge fundamental regulatory mechanisms across inhibitory immune checkpoint receptors that are of great importance in resistance to cancer ...

Resistance to Checkpoint Inhibition in Cancer Immunotherapy. Transl Oncol. 2020 Mar;13(3):100738. doi: 10.1016/j.tranon.2019.12.010. Epub 2020 Feb 27.

Mechanisms of resistance to immune checkpoint inhibitors - Nature

Whereas cytotoxic chemotherapy and small molecule inhibitors ('targeted therapies') largely act on cancer cells directly, immune checkpoint ...

The molecular and functional landscape of resistance to immune ...

Resistance to immune checkpoint inhibitor therapies in melanoma is common and remains an intractable clinical challenge.

Overcoming acquired resistance to cancer immune checkpoint therapy

Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues ...

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Evidence for key oncogenic processes that can potentially foster resistance to immunotherapy includes: (i) oncogenic cooperation, (ii) exclusion of CD8+ T cells ...

The Four Categories of Checkpoint Inhibitor Resistance in Lung ...

Four categories of resistance to CPIs have been proposed: (1) inhibitory or other checkpoints, (2) defects in neoantigen loss and antigen presentation, (3) ...

Full article: A landscape of checkpoint blockade resistance in cancer

Evidence indicates that mutations and epigenetic modifications in the cancer DNA that alter the antigen processing and presentation machinery can contribute to ...

Immune Checkpoint Inhibitors in Cancer Therapy—How to ... - MDPI

Immune checkpoint inhibitors (ICIs), antagonists used to remove tumor suppression of immune cells, have been widely used in clinical settings. Their high ...

Mechanisms of tumor resistance to immune checkpoint blockade ...

Here, we focused on the changes in the biological functions of CD8 + T cells to elucidate the underlying resistance mechanisms of ICB therapies.

Acquired resistance for immune checkpoint inhibitors in cancer ...

Drug resistance has become an obstacle to the further development of immunotherapy in clinical applications and experimental studies.

Mechanisms of Resistance to Immune Checkpoint Blockade

The tumor microenvironment, tumor immunogenicity, antigen presentation, and classic oncologic pathways play roles in response and resistance to immune ...

Genomic and molecular alterations associated with primary ...

The clinical response to immune checkpoint inhibitors may vary by tumor type and many tumors present with either primary or acquired ...

Society for Immunotherapy of Cancer (SITC) consensus definitions ...

Immune checkpoint inhibitors (ICIs) as single agents or in combinations with chemotherapies and targeted therapies are now the standard of care ...

Predictive Biomarkers and Resistance Mechanisms of Checkpoint ...

Predictive biomarkers for immune checkpoint inhibitors (ICIs) in solid tumors such as melanoma, hepatocellular carcinoma (HCC), colorectal cancer (CRC), ...

Acquired Resistance to Immune Checkpoint Inhibitors: Cancer Cell

Despite the characteristic durability of response to ICI, unfortunately many patients with initial response will later develop acquired ...

Resistance to immune checkpoint inhibitors in gastric cancer

In this review, we focus on summarizing the mechanisms of primary or acquired resistance to ICI immunotherapy in GC from both internal and external aspects of ...

Cancer immunotherapy resistance based on immune checkpoints ...

Tumor resistance to immunotherapy based on immune checkpoint inhibitors (ICIs). Contrary to conventional cytotoxic chemotherapy and radiotherapy, which affect ...

Checkpoint Inhibitors: Overcoming Resistance

Checkpoint inhibitors work against cancer by releasing the brakes on the immune system so it can attack and kill tumors more efficiently.

Immune-checkpoint inhibitor resistance in cancer treatment

In the present review, different mechanisms of ICI resistance have been summarized according to the tumor intrinsic, tumor microenvironment (TME) and host ...