Resisting Resistance to Immune Checkpoint Therapy

Resisting Resistance to Immune Checkpoint Therapy: A Systematic ...

This paper provides an overview of the mechanisms of resistance to immune checkpoint inhibitors and highlights the possible therapeutic approaches under ...

Resisting Resistance to Immune Checkpoint Therapy: A Systematic ...

Although long-lasting durable responses have been observed with immune checkpoints inhibitors, the response rate remains relatively low in many ...

Mechanisms of resistance to immune checkpoint inhibitors - Nature

Whereas cytotoxic chemotherapy and small molecule inhibitors ('targeted therapies') largely act on cancer cells directly, immune checkpoint ...

Overcoming acquired resistance to cancer immune checkpoint therapy

The combination of oncolytic virotherapy and ICI therapy is a promising approach. Similar to self vaccination, oncolytic virustherapy could also ...

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term survival outcomes, are mostly effective in patients with immune-responsive ...

The molecular and functional landscape of resistance to immune ...

Resistance to immune checkpoint inhibitor therapies in melanoma is common and remains an intractable clinical challenge.

Mechanisms of Resistance to Immune Checkpoint Blockade

Multiple studies demonstrated that downregulation of MHC class I (MHC-I) allows tumor cells to resist immune surveillance. Loss of function of ...

Mechanisms of tumor resistance to immune checkpoint blockade ...

Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for various cancer types. Multiple single or combinations of ICB treatments ...

Resisting Resistance to Immuno-Checkpoint Therapy - MDPI

Inhibitory immune checkpoints such as PD‐1/PD‐L1 normally maintain peripheral tolerance by disabling the activation and effector functions of autoreactive T‐ ...

Acquired resistance for immune checkpoint inhibitors in cancer ...

An alternative scenario includes immune escape, by which ICIs exhibit an initial therapeutic effect and drug-resistant tumor cell clones that exist inherently ...

Cancer immunotherapy resistance based on immune checkpoints ...

In this regard, immunotherapy based on immune checkpoints inhibitors (ICIs) is a common clinical approach for treatment of patients with poor prognosis when ...

Acquired Resistance to Immune Checkpoint Blockades - Frontiers

The immune checkpoint blockade therapy has completely transformed cancer treatment modalities because of its unprecedented and durable clinical responses in ...

Resisting Resistance to Immune Checkpoint Therapy: A Systematic ...

An overview of the mechanisms of resistance to immune checkpoint inhibitors is provided and the possible therapeutic approaches under investigation aiming ...

Resisting resistance to cancer immunotherapy - Wiley Online Library

Observations of acquired resistance to immune checkpoint blockade occurring in a substantial proportion of patients enrolled in clinical trials ...

Resisting Resistance to Immune Checkpoint Therapy - ResearchGate

This paper provides an overview of the mechanisms of resistance to immune checkpoint inhibitors and highlights the possible therapeutic ...

Acquired Resistance to Immune Checkpoint Blockade Therapies

The main driver for this type of acquired resistance is the small proportion of tumor cells that are resistant to ICBT from the onset of treatment. This ...

Mechanism of resistance to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) have revolutionized the management of cancer over the last decade. Instead of targeting the cancer cell directly these ...

Resisting Resistance to Immune Checkpoint Therapy - Ex Libris

The treatment landscape in oncology has witnessed a major revolution with the introduction of checkpoint inhibitors: anti-PD1, anti-PDL1 and anti-CTLA-4.

Overcome resistance to immune checkpoint inhibitors in NSCLC

Immune checkpoint inhibitors (ICIs) have transformed the treatment of non-small cell lung cancer (NSCLC). However, resistance occurs in almost all patients.

Addressing Resistance to Immune Checkpoint Inhibitor Therapy

Immuno-oncology agents, including immune checkpoint inhibitors (ICIs), have revolutionized the treatment of a range of cancer types [Citation1–3]. Checkpoint ...