Review Mitochondrial dysfunction in amyotrophic lateral sclerosis

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid ...

Converging evidence suggests that impaired mitochondrial function could be pivotal in the rapid neurodegeneration of this condition. In this review, we provide ...

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral ...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal neurodegenerative disease. Although the pathogenesis of ALS ...

Review Mitochondrial dysfunction in amyotrophic lateral sclerosis

In this review, we will discuss how mitochondrial dysfunction has been linked to the ALS variants of SOD1 and the mechanisms by which mitochondrial damage ...

The role of mitochondria in amyotrophic lateral sclerosis

Mitochondrial dysfunction is a prevalent feature of many neurodegenerative diseases including motor neuron disorders such as amyotrophic lateral sclerosis (ALS ...

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), a type of motor neuron disease (MND), is a rapidly progressive, incurable and fatal neurodegenerative ...

Mitochondria, a Key Target in Amyotrophic Lateral Sclerosis ... - MDPI

Mitochondrial dysfunction occurs in numerous neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS), where it contributes to motor ...

Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis ...

Mitochondrial dysfunction in ALS patients has been known for more than 50 years, and the involvement of mitochondria in the pathophysiology of this disease is ...

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral ...

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are ...

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics - Frontiers

Amyotrophic lateral sclerosis (ALS) is a progressive and devastating multifactorial neurodegenerative disorder. Although the pathogenesis of ALS is still ...

Mitochondrial dysfunction in familial amyotrophic lateral sclerosis

However, the exact nature of the link between mutant SOD1 and mitochondrial dysfunctions remains to be established. Here, we briefly review the ...

Mitochondrial dysregulation occurs early in ALS motor cortex with ...

Therefore, it is no surprise that mitochondrial dysfunction emerges as one of the common causes of neurodegeneration in many different diseases, ...

Skeletal muscle dysfunction in amyotrophic lateral sclerosis

Skeletal muscle in ALS is primarily affected by oxidative stress, mitochondrial dysfunction, and bioenergetic abnormalities [3]. The brain is an ...

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis

N2 - Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral ...

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic ...

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by declining motor and cognitive functions.

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis

Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral sclerosis.

Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis

Mitochondria, which play crucial roles in excitotoxicity, apoptosis and cell survival, have shown to be an early target in ALS pathogenesis and contribute to ...

Mechanistic Insights of Mitochondrial Dysfunction in Amyotrophic ...

In this review, we first provide an update of the last lustrum on the molecular mechanisms by which the most well-known ALS-related proteins ...

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

Neuronal mitochondria dysfunction is one of the earliest features of ALS. Mitochondria are highly dynamic organelles that undergo continuous ...

Mitochondrial dysfunction in amyotrophic lateral sclerosis

Mitochondria, which play crucial roles in excitotoxicity, apoptosis and cell survival, have shown to be an early target in ALS pathogenesis and contribute to ...

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral ...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal neurodegenerative disease. Although the pathogenesis of ALS remains unclear, ...