Review Regulation and function of the p53 tumor suppressor protein

Regulation and function of the p53 tumor suppressor protein - PubMed

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of ...

p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function ...

The Regulation of p53 Growth Suppression - NCBI

The p53 tumor suppressor protein plays a key role in the regulation of the cell cycle and cell death. The p53 protein is also involved in cell ...

Regulation of the p53 Tumor Suppressor Protein

These cellular effects of wild type p53 can reduce cancer incidence through elimination of cancer-prone cells from the replicative pool. However, such effects ...

Tumor suppressor p53: regulation and function - IMR Press

The p53 protein is a transcription factor involved in maintaining genomic integrity by controlling cell cycle progression and cell survival.

Mechanisms of transcriptional regulation by p53 - Nature

p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions.

Review Tumor suppressor p53: Biology, signaling pathways, and ...

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears ...

Targeting p53 pathways: mechanisms, structures and advances in ...

Mutations in TP53 not only impair its tumor suppressor function, but also confer oncogenic properties to p53 mutants. Since p53 is mutated and ...

Tumor suppressor p53: from engaging DNA to target gene regulation

The p53 transcription factor confers its potent tumor suppressor functions primarily through the regulation of a large network of target genes.

p53 Tumor Suppressor: Functional Regulation and Role in Gene ...

p53 is tumor-suppressor protein also named as “the guardian of the genome” since it prevents damaged DNA from getting inserted into genome and its proliferation ...

p53 signaling in cancer progression and therapy

Tumor suppression is the main function of p53 protein, which is encoded by the TP53 gene on human chromosome 17. The p53 protein is posited to ...

p53 modifications: exquisite decorations of the powerful guardian

The last 40 years have witnessed how p53 rose from a viral binding protein to a central factor in both stress responses and tumor suppression. The exquisite ...

Ryan, K. M., Phillips, A. C. & Vousden, K. H. Regulation and function ...

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a ...

The p53 tumor suppressor protein: meeting review - Genes Dev

clues as to its function and regulation. Among the new binding sites ... Tumor-derived mutant p53 proteins display gain o[ function. The fact that there ...

(PDF) Tumor suppressor P53: Regulation and function

PDF | The p53 protein is a transcription factor involved in maintaining genomic integrity by controlling cell cycle progression and cell survival.

Regulation and function of the p53 tumor suppressor protein - Ex Libris

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of ...

Posttranslational Regulation of p53 Tumor Suppressor Protein ...

(1992a). The conformational hypothesis of regulation of p53 function states that the conformation of p53 determines whether it expresses growth-suppressing or ...

The regulation of the function of the tumor suppressor protein p53

The p53 tumor suppressor protein is an important regulator of cell fate. Multiple Completion. A question or incomplete statement is followed by ...

Review - Cell Press

So how does p53 contribute to the regulation of metabolism, and how might this help it to function as a tumor suppressor? Not surprisingly, p53 can be activated ...

Shaping the regulation of the p53 mRNA tumour suppressor

The p53 tumor suppressor and its main regulator, the MDM2 E3 ubiquitin ligase, constitute a fine model to understand molecular co-evolution, conservation and ...