Revisiting the role of CD4 T cells in cancer immunotherapy

Revisiting the role of CD4 T cells in cancer immunotherapy—new ...

Revisiting the role of CD4+ T cells in cancer immunotherapy—new ...

In this review, we give an overview of the multifaceted role of CD4 + T cells in the anti-tumour immune response, with an emphasis on recent evidence that CD4 ...

Revisiting the role of CD4+ T cells in cancer immunotherapy-new ...

We illustrate their direct anti-tumour potency and their role in directing a sustained immune response against tumours. We further highlight the ...

Revisiting the role of CD4+ T cells in cancer immunotherapy—new ...

While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8 + cytotoxic T cell response, the potential role of CD4 + 'helper' T cells ...

Revisiting the role of CD4 T cells in cancer immunotherapy—new ...

Revisiting the role of CD4 T cells in cancer immunotherapy—new insights into old paradigms-article.

[PDF] Revisiting the role of CD4+ T cells in cancer immunotherapy ...

The emerging observation that CD4 + T cell responses against tumours tend to be against self-derived epitopes raise vital questions and considerations that ...

Revisiting the role of CD4+ T cells in cancer - ProQuest

Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly ...

Revisiting the role of CD4(+)T cells in cancer immunotherapy-new ...

While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8(+)cytotoxic T cell response, the potential role of CD4(+)'helper' T cells ...

The role of CD4+ CAR T cells in cancer immunotherapy - PMC

The direct anti-tumour cytotoxic function of CD8+ T cells is widely appreciated. By contrast, CD4+ T cells are traditionally considered to operate primarily as ...

Revisiting the role of CD4+ T cells in cancer immunotherapy—new ...

While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8+ cytotoxic T cell response, the potential role of CD4+ 'helper' T cells ...

The role of CD4+ CAR T cells in cancer immunotherapy - Bove

The direct anti-tumour cytotoxic function of CD8+ T cells is widely appreciated. By contrast, CD4+ T cells are traditionally considered to ...

Revisiting the role of CD4+ T cells in cancer immunotherapy—new ...

AbstractCancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly ...

The importance of CD4 T cells in developing cancer vaccines

This article focuses on how the immune system can promote successful tumour remission, highlighting the crucial role of CD4 T cells and neoantigens.

Revisiting the role of CD4 T cells in cancer immunotherapy—new ...

Revisiting the role of CD4 T cells in cancer immunotherapy—new insights into old paradigms-article.

CD4 and CD8 T lymphocyte interplay in controlling tumor growth

In contrast, the role of CD4 T cell immunity to cancer is much less understood. It has now become increasingly clear that tumor-specific CD4 T ...

Revisiting the role of CD4 + T cells in cancer immunotherapy—new ...

While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8+ cytotoxic T cell response, the potential role of CD4+ 'helper' T cells has ...

The Era of Cytotoxic CD4 T Cells - Frontiers

In contrast, the existence and function of CD4 CTLs in cancer remain unclear. Seminal preclinical studies by Allison's group demonstrated that CD4 CTLs can ...

Impact of Immunotherapy on CD4 T Cell Phenotypes and Function ...

Indeed, we recently identified CD4 T cells with cytotoxic phenotypes involved in the direct elimination of tumor cells in different human cancer types [18].

CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in ...

CD4 T cells taken from the recurrent tumors expressed fewer cytokines, increased levels of coinhibitory receptors (112), and were unable to induce tumor ...

Differential requirements for CD4+ T cells in the efficacy of the anti ...

CD4+ and CD8+ T cell depletion, tetramer binding assays and ELISPOT assays were used to demonstrate the unique role of CD4+T cell help in the antitumor effects ...

Revisiting T Cell Tolerance as a Checkpoint Target for Cancer ...

CD8+ T cells are considered one of the main targets of cancer immunotherapy (5). In particular, there is strong evidence that a primary mechanism underlying ...