Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

Atherosclerosis, for which hyperlipidemia is a major risk factor, is the leading cause of morbidity and mortality in Western society, ...

Role of thermogenic adipose tissue in lipid metabolism ... - PubMed

Studies in mice have shown that activation of thermogenesis in brown and beige adipocytes enhances the lipolytic processing of triglyceride-rich ...

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis.

This work proposes a model in which activated brown adipocytes use their intracellular triglyceride stores to generate fatty acids for combustion, ...

Role of thermogenic adipose tissue in lipid metabolism and ...

The (re-)discovery of active brown adipose tissue (BAT) in adult humans opened a new window of therapeutic opportunities for atherosclerotic CVD ...

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis.

Through these mechanisms, BAT activation reduces plasma triglyceride and cholesterol levels and attenuates diet-induced atherosclerosis development. Initial ...

Brown fat activation reduces hypercholesterolaemia and protects ...

Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity.

Linking white-to-brown fat remodeling to fatty acid and lipoprotein ...

Objectives: Brown adipose tissue (BAT) activation lowers plasma triglyceride-rich lipoprotein levels through the action of lipoprotein lipase (LPL).

Brown Adipose Tissue Activation Is Involved in Atherosclerosis of ...

Atherosclerotic plaque growth was associated with the disturbance of lipid metabolism and UCP1 has been reported involved in lipid metabolism. Due to this, we ...

Beneficial effects of brown fat activation on top of PCSK9 inhibition ...

Brown fat, which is a metabolically active tissue in mammals including humans [11], [12] and characterized by a large number of mitochondria and small lipid ...

Does activating brown fat contribute to important metabolic benefits ...

Adipose tissues are organs that have vital physiological roles in human health and disease. Functionally, white adipose tissue (WAT) is the ...

Colesevelam enhances the beneficial effects of brown fat activation ...

BA sequestration prevents the marked accumulation of plasma BAs as induced by prolonged brown fat activation, thereby further improving cholesterol metabolism ...

Unravelling the mechanism and importance of brown adipose tissue ...

Objectives: Brown adipose tissue (BAT) has been shown to be a major player of lipid metabolism contributing to the effective reduction of plasma lipid levels.

Role of brown adipose tissue in metabolic health

Brown adipose tissue has recently emerged as an important player in energy metabolism as it dissolves high amounts of lipid and glucose into heat.

Interaction between adipocytes and high-density lipoprotein:new ...

Nowadays, there is increasing evidence that adipose tissue has a potential contribution to HDL metabolism. Considering the large area of fat ...

Lipid Transport in Brown Adipocyte Thermogenesis - Frontiers

Historically, research on thermogenic adipocytes has focused on glycolytic metabolism due to the discovery of active brown adipose tissue in adult humans ...

Brown adipose tissue derived ANGPTL4 controls glucose and lipid ...

Our findings demonstrate an important role of BAT derived ANGPTL4 in regulating lipoprotein metabolism, whole-body lipid and glucose metabolism, and ...

VLDL-VLDLR axis facilitates brown fat thermogenesis through ...

elevated lipoprotein metabolism upon cold stimuli. The findings that ... The brown fat secretome: metabolic functions beyond thermogenesis.

The role of active brown adipose tissue (aBAT) in lipid metabolism in ...

The mitochondrial inner membrane of brown fat cells is rich in uncoupling protein 1 (UCP l), which converts chemical energy into thermal energy ...

Brown Adipose Tissue Activation Is Linked to Distinct Systemic ...

However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, ...

A new, powerful player in lipoprotein metabolism: brown adipose ...

... atherosclerosis in murine models. Curr Drug Targets 8:1307 ... Rothwell NJ, Stock MJ (1979) A role for brown adipose tissue in diet-induced thermogenesis.