Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein ...

IRE1 as an ER stress sensor needs to be understood from a wider perspective for comprehensive functional meaning, which facilitates us with assembling ...

Emerging roles for the ER stress sensor IRE1α in metabolic ...

Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)-resident transmembrane protein that senses ER stress and is evolutionarily conserved ...

Decoding non-canonical mRNA decay by the endoplasmic ... - Nature

Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR).

Endoplasmic reticulum stress activates human IRE1α through ... - eLife

One such oligomer-forming protein is the ER membrane-resident stress sensor IRE1. It is a dual-function kinase/ribonuclease (RNase) responsible ...

Beyond UPR: cell-specific roles of ER stress sensor IRE1α in kidney ...

The IRE1α-XBP1 signaling acts as a major arm of unfolded protein response and is involved in regulating autophagy, cell differentiation, and ...

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

Furthermore, IRE1α are in normal cell activities outside the dominion of ER stress and activities under the weather of inflammation, diabetes, ...

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

A IRE1α signal pathway arbitrates yin and yang of cellular fate in objectionable conditions. It plays several roles in fundamental cellular ...

Emerging roles for the ER stress sensor IRE1α in metabolic ...

Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)-resident transmembrane protein that senses ER stress and is ...

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated ...

IRE1α induces the cell death pathway by activating different apoptosis-inducing molecules through its endonuclease and kinase functions (Figure 1C). However, ...

The endoplasmic reticulum stress sensor IRE1α modulates ...

ER stress induces the unfolded protein response (UPR), a conserved response broadly associated with innate immunity and cell metabolic function in various ...

The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV ...

Among the UPR regulators, IRE1α functions as a dual protein kinase and endoribonuclease (a ribonuclease [RNase]). The RNase causes unconventional splicing of ...

IRE1β negatively regulates IRE1α signaling in response to ...

All mammalian cell types have three sensors in the ER, IRE1α, ATF6, and PERK, which detect imbalances in protein folding and trigger an ...

Mammalian endoplasmic reticulum stress sensor IRE1 signals by ...

If homeostasis in the ER protein folding environment cannot be reestablished, cells commit to apoptosis. The ER-resident transmembrane kinase-endoribonuclease ...

The aftermath of the interplay between the endoplasmic reticulum ...

Upon ER stress, the UPR, primarily functions to achieve cellular adaptation by maintaining ER homeostasis. However, the UPR and ER stress ...

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) ...

Multiple Ways for Stress Sensing and Regulation of the ... - J-Stage

Dysfunction of the endoplasmic reticulum (ER), so-called ER stress, is accompanied with accumulation of unfolded proteins in the ER.

A stress sensor, IRE1α, is required for bacterial-exotoxin-induced ...

Here, we clarify the roles of inositol-requiring enzyme 1 alpha (IRE1α), an endoplasmic reticulum (ER) stress sensor, in CT-induced IL-1β production in RPMs. In ...

Membrane aberrancy and unfolded proteins activate the ...

Eukaryotic cells activate the unfolded-protein response (UPR) upon endoplasmic reticulum (ER) stress, where the stress is assumed to be the ...

Endoplasmic Reticulum Stress Sensor IRE1α | Encyclopedia MDPI

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) ...