Role of EphA4 in Mediating Motor Neuron Death in MND

Role of EphA4 in Mediating Motor Neuron Death in MND - PMC - NCBI

In this review, we first present results to demonstrate that EphA4 signalling acts directly on motor neurons to cause cell death.

Role of EphA4 in Mediating Motor Neuron Death in MND - PubMed

As progressive motor neuron cell death is one of pathological characteristics of MND, molecules which protect these cells are attractive ...

(PDF) Role of EphA4 in Mediating Motor Neuron Death in MND

As progressive motor neuron cell death is one of pathological characteristics of MND, molecules which protect these cells are attractive ...

Role of EphA4 in Mediating Motor Neuron Death in MND - OUCI

Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of ...

Eph receptor A4 regulates motor neuron ferroptosis in spinal cord...

Inhibition of the Xc – system function ultimately induces neuronal ferroptosis (Dixon et al., 2012). EphA4 signaling induces glutamate excitotoxic neuronal ...

Inducible EphA4 knockout causes motor deficits in young mice and ...

... motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4) ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Reduction of EphA4 did not improve motor function, survival, motor neuron survival or NMJ innervation. Our data suggest that either lowering EphA4 has limited ...

WO2012156351A1 - Epha4 is a disease modifier in motor neuron ...

Resistent motor neurons in late-symptomatic SOD1G93A mice have lower EphA4 levels. EphA4 expression in ventral horn (motor) neurons in the lumbal spinal cord of ...

Role of EphA4 signaling in the pathogenesis of amyotrophic lateral ...

There is a critical unmet need for novel therapeutic drugs for ALS and it is likely that EphA4 genetically modulates the vulnerability of motor neurons to ...

(PDF) EphA4 targeting agents protect motor neurons from cell death ...

The complex interplay between EphA4 receptor and its ephrin ligands in motor neurons and astrocytes has not yet been fully elucidated, and includes a putative ...

Motor Neuron Disease | Encyclopedia MDPI

Preventing this death is the primary therapeutic aim. Here we discuss the importance of EphA4 signalling in motor neuron cell death, the mechanisms of ...

Reducing EphA4 before disease onset does not affect survival in a ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons resulting in severe neurological symptoms.

Motor neuron death in ALS: programmed by astrocytes? - Europe PMC

Non-cell autonomous mediators of cell death derived from activated astrocytes contribute to necroptosis mediated motor neuron demise. Presence of mutant SOD1 in ...

Translating biological findings into new treatment strategies for ...

These observations suggest an active involvement of the inhibitory system in mediating the axonal sprouting properties of neurons. In the ephrin system, the ...

Motor neuron vulnerability and resistance in amyotrophic lateral ...

MN counts in brainstem nuclei of end-stage SOD1G86R mice revealed a 48% loss of MNs in the vulnerable facial nucleus, but only a 6% loss in the ...

Motor Neuron Death in ALS: Programmed by Astrocytes?

29 Citations · Role of EphA4 in Mediating Motor Neuron Death in MND · Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets ...

Trial planned for potential treatment for motor neurone disease

Professor Bartlett's research has previously shown that a protein called EphA4 regulates MND progression through its involvement of motor neuron ...

Decreased signalling of EphA4 improves functional performance ...

Our novel results show that EphA4 signalling directly regulates motor neuron survival and that mutEphA4-Fc is a promising therapeutic candidate to slow disease ...

Why should we care about astrocytes in a motor neuron disease?

... role in neuronal distress and cell death. At least two broad ... Recently, synthetic EphA4 agonists were shown to prevent astrocyte-mediated motor neuron ...

Special Issue : Eph Receptors and Ephrins - IJMS - MDPI

Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of ...