Role of Immune Microenvironment in Pancreatic Ductal ...

Role of Immune Microenvironment in Pancreatic Ductal ... - PubMed

Despite the retrospective nature and small sample size, our study showed that the high infiltration of CD8+ lymphocytes and low infiltration ...

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly immunosuppressive tumor microenvironment (TME).

Tumor immune microenvironment-based therapies in pancreatic ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor immune microenvironment (TIME) formed by ...

Innate and adaptive immune-directed tumour microenvironment in ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumours in humans. It is the most frequent form of pancreatic cancer, 90% ...

Tumour microenvironment of pancreatic cancer: immune landscape ...

This review focuses on the characteristics of the local immune contexture of pancreatic ductal adenocarcinoma and the interaction between tumour cells and ...

Pancreatic cancer tumor microenvironment is a major therapeutic ...

Pancreatic cancer cells (PCC) arise from either ductal pancreas cells or acinar pancreas cells. Acinar cells perform the role of digestive enzyme production and ...

Dynamic profiling of immune microenvironment during pancreatic ...

Pancreatic ductal adenocarcinoma (PDAC) has little response to immune checkpoint inhibitors. An in-depth understanding of the immune microenvironment from a ...

The Tumor Immune Microenvironment in Pancreatic Ductal ... - MDPI

However, it is increasingly recognized that T cells play dual roles to permit and, when activated, suppress tumor progression in PDAC. A recent ...

Pancreatic ductal adenocarcinoma immune microenvironment and ...

Tumor-reprogrammed myeloid cells not only create a tolerogenic environment by blocking T cell functions and proliferation, but also promote tumor growth by ...

The role of innate immune cells as modulators of the tumor ...

The tumor microenvironment of pancreatic cancer, which comprises pancreatic cancer cells, stromal cells, and immune cells, as well as a ...

Perineural Invasion Reprograms the Immune Microenvironment ...

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the ...

The Immune Microenvironment in Pancreatic Cancer - MDPI

In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor–stroma ...

Immune microenvironment and immunotherapy in pancreatic cancer

TAMs are important immune cells in tumor tissue, and these cells play a vital role in the genesis, development, metastasis, and immune escape of pancreatic ...

Molecular and metabolic regulation of immunosuppression in ...

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival.

Targeting the tumor microenvironment for pancreatic ductal ...

The microenvironment of PDAC, which promotes tumorigenesis, disease development and metastasis, consists of fibroblasts, immune cells, pancreatic stellate ...

Crosstalk between the Tumor Microenvironment and Immune ...

The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate ...

Immune cell infiltration as an indicator of the immune ... - Nature

The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating ...

Role of Immune Cells and Immune-Based Therapies in Pancreatitis ...

Although macrophages are a major leukocyte population found in the inflamed pancreas, T cells are also present in smaller numbers at sites of inflammation.

The tumor immune microenvironment in pancreatic ductal ...

The tumor immune microenvironment in pancreatic ductal adenocarcinoma involves complex, opposing interaction networks. Presence of both "hot" (red circle) ...

The Tumor Immune Microenvironment in Pancreatic Ductal ... - OUCI

Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response.