Role of Plasminogen|Activator Inhibitor Type 1 in the Pathogenesis ...

Role of plasminogen-activator inhibitor type 1 in the ... - PubMed

Our studies suggest that PAI-1 is the circulating inhibitor of fibrinolysis in the hemolytic uremic syndrome. Normalization of plasma PAI-1 ...

Role of Plasminogen-Activator Inhibitor Type 1 in the Pathogenesis ...

Conclusions. Our studies suggest that PAI-1 is the circulating inhibitor of fibrinolysis in the hemolytic uremic syndrome. Normalization of ...

Plasminogen activator inhibitor-1 in the pathogenesis of asthma

Plasminogen activator inhibitor (PAI)-1 is the main inhibitor of the fibrinolytic system and is known to play an essential role in tissue remodeling.

Role of Plasminogen-Activator Inhibitor Type 1 in the Pathogenesis ...

Our studies suggest that PAI-1 is the circulating inhibitor of fibrinolysis in the hemolytic uremic syndrome. Normalization of plasma PAI-1 ...

The role of plasminogen activator inhibitor type 1 in the inflammatory ...

Background: The plasma levels of the plasminogen activator‐inhibitor type 1 (PAI‐1) are consistently elevated in patients with sterile tissue injury, ...

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and ...

In addition to this function, PAI-1 acts as an acute-phase protein during acute inflammation. PAI-1 is a pivotal player in the pathogenesis of sepsis, a complex ...

Plasminogen activator inhibitor‐1: a potential etiological role in ...

PAI-1 also plays a role in many other physiological processes and activities, including thrombosis, fibrosis, wound healing, angiogenesis, ...

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary ...

Plasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the fibrinolysis system and thrombosis.

Role of Plasminogen Activator Inhibitor-1 in Glucocorticoid-Induced ...

The pathogenic mechanism, however, is not completely understood. In this study, we used plasminogen activator inhibitor-1 (PAI-1)–deficient mice ...

Plasminogen activator inhibitor-1, inflammation, obesity, insulin ...

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase type plasminogen activator (u- ...

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its ...

Through urokinase-type PA (uPA)-mediated plasminogen activation, the function of the plasminogen/plasmin system extends to pericellular proteolysis associated ...

Plasminogen activator inhibitor‐1 and asthma: role in the ...

PAI-1 levels are markedly increased in asthmatic airways, and mast cells (MCs), a pivotal cell type in the pathogenesis of asthma, are one of ...

Plasminogen Activator Inhibitor-1 and Thrombotic Cerebrovascular ...

The roles of these 3 inhibitors are complementary in thrombolysis. ... PAI-1 has become recognized as a central molecule linking pathogenesis and ...

Aging and plasminogen activator inhibitor-1 (PAI-1) regulation

Interleukin-6 probably plays an important pathogenic role in a variety of disorders associated with chronic stress and physiological aging [93], such as the ...

Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver ...

PAI-1 has been studied to understand its pathogenic role in fibrosis and to use it as a therapeutic strategy. However, some conflicting results raise major ...

Association between plasminogen activator inhibitor-1 and ...

Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings ...

Plasminogen Activator Inhibitor 1 - American Journal of Physiology

PAI-1 is the major inhibitor of plasminogen activation by tissue-type (t-) and urokinase-type (u-) plasminogen activator (PA). t-PA is generally thought to be ...

Plasminogen activator inhibitor-1 - Wikipedia

PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), the ...

The Role of Type 1 Plasminogen Activator Inhibitor in the Regulation ...

Levin, E.G., Santell, L.: Association of plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells. J. Cell.

Role of Plasminogen Activator Inhibitor Type 1 in the Pathogenesis ...

Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an ...