Role of SHIP2 in cell repulsion regulated by Eph receptor ...

Role of SHIP2 in cell repulsion regulated by Eph receptor ... - bioRxiv

There is thus a distinct mode of interaction from EphA2, which binds SHIP2 via its SAM domain. Knockdown of SHIP2 in EphB2 cells leads to ...

Role of SHIP2 in cell repulsion regulated by Eph receptor ... - bioRxiv

Eph receptor and ephrin signaling can drive cell segregation by regulating the strength of cell adhesion, repulsion and/or cortical tension at ...

Role of SHIP2 in cell repulsion regulated by Eph receptor and ...

Eph receptor and ephrin signaling can drive cell segregation by regulating the strength of cell adhesion, repulsion and/or cortical tension at ...

Regulation of EphA2 Receptor Endocytosis by SHIP2 Lipid ...

role for SHIP2 in regulating phosphoinositol lipids to modulate. Eph receptor function in cancer cells. Recruitment of SHIP2 to the Activated EphA2 Receptor via ...

Eph receptor signalling: from catalytic to non-catalytic functions

Receptor tyrosine kinases (RTKs) are a major type of membrane receptors, which govern cell proliferation, differentiation and mobility [1].

Emerging strategies for EphA2 receptor targeting for cancer ...

The interaction of Eph receptors with Ephrins is known to mediate cell-cell repulsion, regulate axon outgrowth, restrict cell migration and maintain well ...

Regulation of EphA2 Receptor Endocytosis by SHIP2 Lipid ...

It is shown that SHIP2 (Src homology 2 domain-containing phosphoinositide 5-phosphatase 2) is recruited to activated EphA2 via a heterotypic sterile α motif ...

EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold ...

Ashlin, T.G., Wu, Z., Xu, Q., and Wilkinson, D.G. (2019). Role of SHIP2 in cell repulsion regulated by Eph receptor and ephrin signaling.

EphA Receptor Signaling – Complexity and Emerging Themes - PMC

EphA2 receptor activation by ligand stimulation enhances cell-cell adhesion and inhibits growth factor-mediated chemotaxis/scattering thereby promotes MET or ...

Cellular and molecular mechanisms of EPH/EPHRIN signaling in ...

Upon EPHRIN-A1 stimulation, SHIP2 binds to the EPHA2 SAM domain and inhibits EPHA2 endocytosis, independent of EPHA2 kinase activity (Zhuang, Hunter, Hwang, & ...

Cellular and molecular mechanisms of EPH/EPHRIN signaling in ...

Role of SHIP2 in cell repulsion regulated by Eph receptor and ephrin signaling. https://doi.org/10.1101/872846. Ashton, R. S., Conway, A., Pangarkar, C ...

Specific Eph receptor-cytoplasmic effector signaling mediated by ...

Here, we systematically investigated the bindings of each SAM domain of Eph receptors to the SAM domains from SHIP2 and Odin, and uncover a ...

Protein kinase A can block EphA2 receptor–mediated cell repulsion ...

The EphA2 receptor tyrosine kinase plays key roles in tissue homeostasis and disease processes such as cancer, pathological angiogenesis, ...

Eph-Ephrin Bidirectional Signaling in Physiology and Disease: Cell

Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on neighboring cells. The ensuing bidirectional signals have ...

Eph/ephrin molecules—a hub for signaling and endocytosis

Whether this mechanism can also explain the roles of Eph receptors in cell ... Regulation of repulsion versus adhesion by different splice forms of an Eph ...

[PDF] Regulation of EphB2 activation and cell repulsion by feedback ...

Role of SHIP2 in cell repulsion regulated by Eph receptor and ephrin signaling · Tim G. AshlinZhonglin WuQiling XuD. Wilkinson. Biology, Medicine. bioRxiv. 2019.

Tiam–Rac signaling mediates trans-endocytosis of ephrin receptor ...

Ephrin receptors interact with membrane-bound ephrin ligands to regulate contact-mediated attraction or repulsion between opposing cells, ...

Roles of EphA2 in Development and Disease - MDPI

Eph receptors regulate a diverse range of biological processes including cell proliferation, differentiation, migration and tissue morphogenesis [7,30,31,72,73, ...

Eph receptor and ephrin function in breast, gut, and skin epithelia

Eph receptor and ephrin signaling has emerged as a major regulator of epithelial tissue homeostasis by regulating the organization of stem cell compartments as ...

Eph Receptor Signaling and Ephrins - Cold Spring Harb Perspect Biol

Hsp90 mediated co-receptor function for LRP1 regulates. EphA2-dependent glioblastoma cell invasion. ... Regulation of EphB2 activation and cell repulsion by.