Role of YAP/TAZ in Cell Lineage Fate Determination and ...

Role of YAP/TAZ in Cell Lineage Fate Determination and ... - Frontiers

In this review, we discuss the regulatory mechanisms by which YAP/TAZ control stem/progenitor cell differentiation into the various major lineages.

Role of YAP/TAZ in Cell Lineage Fate Determination and Related ...

In this review, we discuss the regulatory mechanisms by which YAP/TAZ control stem/progenitor cell differentiation into the various major lineages.

(PDF) Role of YAP/TAZ in Cell Lineage Fate Determination and ...

PDF | The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many.

Role of YAP/TAZ in Cell Lineage Fate Determination and Related ...

The key role of YAP/TAZ in maintaining the delicate balance between quiescence, self-renewal, proliferation and differentiation of ...

Role of extracellular matrix and YAP/TAZ in cell fate determination

ECM and YAP/TAZ are key regulators in mechanotransduction. Abstract. The mechanical signals transduced from cellular microenvironment can regulate cell shape ...

Role of YAP in hematopoietic differentiation and erythroid lineage ...

Although YAP is dispensable for maintaining the self-renewal and pluripotency of these hiPSCs, it affects the early cell-fate determination and ...

YAP/TAZ functions and their regulation at a glance

In the nucleus, they pair with DNA-binding factors of the TEAD family to regulate gene expression. Nuclear YAP/TAZ promote cell proliferation, ...

Context-dependent roles of YAP/TAZ in stem cell fates and cancer

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms, including transcriptional regulation of key genes.

Yap and Taz promote osteogenesis and prevent chondrogenesis in ...

Thus, Yap and Taz promote osteogenic lineage commitment in NCCs by both promoting one cell fate and repressing another. Abstract. Neural crest ...

Regulation and mechanism of YAP/TAZ in ... - Spandidos Publications

It has been proposed that cell fate induced by stiff ECM requires YAP/TAZ function and, conversely, cell fate associated with soft ECM requires ...

An overview of signaling pathways regulating YAP/TAZ activity

... roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing.

The Hippo signaling pathway in development and regeneration

ECM stiffness is an important regulator in development and cancer. YAP/TAZ activity is induced when cells are cultured on a stiff matrix, and ...

Role of YAP/TAZ in Cell Lineage Fate Determination and Related ...

List of references · Ahmed, FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation., Cell Mol. · Akladios, Positive ...

LATS-YAP/TAZ controls lineage specification by regulating TGFβ ...

The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination and ...

Interplay Between Notch and YAP/TAZ Pathways in the Regulation ...

Notch controls binary cell fate decisions during morphogenesis, while YAP/TAZ transduce physical properties of the microenvironment into critical cell decisions ...

The Biology of YAP/TAZ: Hippo Signaling and Beyond

YAP/TAZ activation also reflects the cell “social” behavior, including cell adhesion and the mechanical signals that the cell receives from tissue architecture ...

The role of Hippo‐YAP/TAZ signaling in brain development

It is well established that the activity of YAP and TAZ mediate a diverse number of growth-related processes, including cellular fate ...

The roles and regulation of Yes-associated protein 1 in stem cells

In porcine muscle stem cells, YAP1 promotes their proliferation at a high cell density (Liu et al., 2021). Yap1/Taz signaling in mesenchymal ...

Context-dependent transcriptional regulations of YAP/TAZ in stem ...

Among these residues, YAP Ser127 and Ser397 phosphorylations were mainly responsible for the suppressive role of Hippo kinase in cell ...

Role of extracellular matrix and YAP/TAZ in cell fate determination

YAP was recently identified as key mediators in response to ECM elasticity and cell shape, and YAP signaling played a critical role in regulation of mechano- ...