Role of the NLRP3 inflammasome in autoimmune diseases

Role of the NLRP3 inflammasome in autoimmune diseases - PubMed

NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that senses foreign pathogens and endogenous danger ...

NLRP3 inflammasome plays a key role in immunity and autoimmune diseases. NLRP3 inflammasome acts as a promising therapeutic target for autoimmune diseases.

NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive ...

The main function of NLRP3 inflammasome is to promote secretion of interleukin (IL)-1β and IL-18, and pyroptosis mediated by caspase-1. Served as a checkpoint ...

Review NLRP3 inflammasome and its role in autoimmune diseases

This review summarizes the structure, assembly, and activation mechanisms of the NLRP3 inflammasome, focusing on its role and involvement in various autoimmune ...

Regulating the NLRP3 Inflammasome in Autoimmune Diseases

Aberrant functions of intracellular NLRP3 inflammasomes promote the occurrence and development of autoimmune diseases, with the majority of ...

NLRP3 inflammasome: a key player in the pathogenesis of life-style ...

The NLRP3 inflammasome is an important sensor and indicator not only of inflammatory immune disorders but also of metabolic disorders, ...

The NLRP3 inflammasome: contributions to inflammation-related ...

Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, ...

Role of NLRP3 Inflammasome in Rheumatoid Arthritis - Frontiers

Recent studies suggest that NLRP3 inflammasome, a regulator of inflammation, might play an important role in the development of RA. There have been increasing ...

Regulating the NLRP3 Inflammasome in Autoimmune Diseases

In summary, the NLRP3 inflammasome-mediated release of IL-1β and IL-18 simultaneously affects innate immunity and adaptive immunity. Dysfunctional NLRP3 ...

The role of inflammasomes in human diseases and their potential as ...

Stimuli, including PAMPs and DAMPs, drive both the priming and activation steps of NLRP3 inflammasome activation. Throughout this process, the ...

Role of inflammasomes in inflammatory autoimmune rheumatic ...

The activation of NLRP3 inflammasome by the assembly with ASC and pro-caspase-1 is induced in RA compared to healthy normal control.

Inflammasome Molecular Insights in Autoimmune Diseases - MDPI

NLRP1, NLRP3, and NLRC4 are components of inflammatory cytoplasmic dimers. They possess a central NBD, a C-terminal leucine-rich repeat (LRR), and a pyrin or ...

The role of NLRP3 inflammasome in aging and age-related diseases

The NLRP3 inflammasome is an indispensable factor in mediating inflammation, and its massive secretion can result in cellular self-damage, ...

The role of NLRP3 inflammasome in type 2 inflammation related ...

However, the exact pathogenesis of these diseases is still unclear. The NLRP3 inflammasome is a protein complex composed of the NLRP3 protein, ...

Role of the NLRP3 inflammasome in autoimmune diseases. - Abstract

Among its various functions, the NLRP3 inflammasome can induce the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 while also promoting ...

Role of the NLRP3 inflammasome in autoimmune diseases.

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review · Medicine.

Inflammasomes and Childhood Autoimmune Diseases: A Review of ...

Genetic variants in components of NOD-like receptor (NLR)-associated inflammasomes, such as NLRP1 and NLRP3, have been reported to be associated ...

NLRP3 Inflammasome and MS/EAE - Inoue - Wiley Online Library

Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS.

Role of the NLRP3 inflammasome in autoimmune diseases

Among its various functions, the NLRP3 inflammasome can induce the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 while also promoting ...

The NLRP3 inflammasome pathway in autoimmune diseases - OUCI

Tian, MiR‐223‐3p inhibits inflammation and pyroptosis in monosodium urate‐induced rats and fibroblast‐like synoviocytes by targeting NLRP3, Clin. Exp. Immunol.