Role of the Vascular Endothelial Growth Factor Pathway in Tumor ...

Role of the vascular endothelial growth factor pathway in tumor ...

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination.

The role of VEGF in the process of tumor angiogenesis via stimulation of VEGFRs on tumor endothelium is well established. However, evidence is emerging that ...

The role of vascular endothelial growth factor (VEGF) in tumor ...

Originally identified for its ability to induce vascular permeability and stimulate endothelial cell growth, VEGF is now known to be a key requirement for tumor ...

The Role of Vascular Endothelial Growth Factor (VEGF) in Tumor ...

Because the VEGFR-2 system is a dominant signal-transduction pathway in regulating tumor angiogenesis, specific inhibitors of this pathway inhibit metastases, ...

Pivotal role of vascular endothelial growth factor pathway in tumor ...

VEGF/VEGFR induces tumor angiogenesis with endothelial cells. When hypoxic stress occurs in tumor cells, transcription of hypoxia-inducible ...

The role of VEGF in cancer-induced angiogenesis and research ...

Tumor endothelial cells with overexpressed VEGF receptors replace the normal ones and make the vessels more sensitive to VEGF. In addition, ...

The pathophysiologic role of VEGF in hematologic malignancies

In addition, co-expression of both VEGF and VEGF receptors in leukemia, lymphoma, and MM, coupled with its direct effects on tumor cell survival, migration, and ...

Vascular Endothelial Growth Factor (VEGF) Pathway

The search for tumor-derived factors that stimulate angiogenesis led to the identification of vascular endothelial growth factor (VEGF, also known as VEGF-A) ...

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

Moreover, VEGF-A is the most important regulator of angiogenesis that plays an irreplaceable role in tumor growth, proliferation, invasion, ...

Vascular Endothelial Growth Factor: Basic Science and Clinical ...

The tyrosine kinases Flt-1 (VEGFR-1) and Flk-1/KDR (VEGFR-2) are high-affinity VEGF receptors. The role of VEGF in developmental angiogenesis is emphasized by ...

Vascular Endothelial Growth Factor Ligands and Receptors in ...

The family of vascular endothelial growth factors influences the process of blood vessel formation within a growing tumor. These proteins promote tumor growth ...

Pivotal role of vascular endothelial growth factor pathway in tumor ...

The main targets of VEGF are endothelial cells, and VEGF is released by cancer cells to induce tumor angiogenesis [6]. The increase of VEGF is ...

Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor ...

The VEGF (vascular endothelial growth factor) pathway has emerged as an important target for cancer therapy, with VEGF signaling pathway ...

The role of the VEGF-C/VEGFR-3 axis in cancer progression - Nature

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, ...

The role of vascular endothelial growth factor in the hypoxic and ...

VEGF, an angiogenesis stimulator, suppresses tumor immunity by inhibiting the maturation of dendritic cells, and induces immunosuppressive cells ...

Vascular Endothelial Growth Factor Signaling Pathways

Importantly, VEGF is released by tumor cells and induces tumor neovascularization. It is now well established that the VEGF axis represents an ...

Structure and function of vascular endothelial growth factor and its ...

Among the angiogenic proteins, VEGF-VEGFR is a crucial regulator of pathological angiogenesis such as in cancer as well as physiological vasculogenesis and ...

Vascular endothelial growth factor and its receptor system

The VEGF-VEGFR system plays crucial roles in tumour angiogenesis. Therefore, anti-angiogenic therapy targeting VEGF signals efficiently suppresses cancer ...

Role of Vascular Endothelial Growth Factor Pathway in Tumor ...

New blood vessel formation (angiogenesis) is fundamental to tumor growth, invasion, and metastatic dissemination. The vascular endothelial growth factor (VEGF) ...

Vascular endothelial growth factor - Wikipedia

Vascular endothelial growth factor originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the ...